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HML II > Hematological malignancy drugs > Flashcards

Hematological malignancy drugs Flashcards

1
Q

First-line treatment for ALL

A

Vincristine + prednisone

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2
Q

Treatment for T cell ALL expressing high levels of ADA

A

Pentostatin/deoxycoformycin

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3
Q

Mechanism of pentostatin

A

ADA inhibitor

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4
Q

Most effective treatment for AML

A

Cytarabine

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5
Q

Combination chemotherapy used in AML

A

Cytarabine + anthracycline

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6
Q

First line therapy for CML

A

Imatinib

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7
Q

Resistance to Imatinib in CML

A

BCR-ABL gene mutation

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8
Q

Side effects of imatinib

A

Diarrhea
Fluid retention
CHF

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9
Q

Mechanism of imatinib

A

Tyrosine kinase inhibitor of BCR-ABL oncogene

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10
Q

Other approved drugs for treating CML

A

Dasatinib
Nilotinib
IFN-alpha
Busulfan
Hydroxyurea

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11
Q

CHOP combination therapy for CLL

A

Cyclophosphamide
Doxorubicin hydrochloride
Vincristine sulfate/oncovin
Prednisone

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12
Q

Other treatment options for CLL

A

Riuximab
Ofatumumab

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13
Q

MOPP combination therapy for Hodgkin’s lymphoma

A

Mechlorethamine
Oncovin/vincristine
Procarbazine
Prednisone

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14
Q

ABVD combination therapy for Hodgkin’s lymphoma

A

Adriamycin/doxorubicin
Bleomycin
Vincristine
Dacarbazine

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15
Q

Two combination therapies used in Hodgkin’s lymphoma

A

MOPP
ABVD –> less toxic and more effective

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16
Q

Combination therapy used in NHL

A

CHOP

17
Q

What can be added to combination therapy in NHL

A

Rituximab + CHOP

18
Q

MP protocol combination therapy in multiple myeloma

A

Melphalan
Prednisone

19
Q

Treatment in refractory or relapsed multiple myeloma

A

Thalidomide

20
Q

First-line therapy for multiple myeloma

A

Bortezomib

21
Q

Mechanism of bortezomib in multiple myeloma

A

Inhibits 26S proteosome causing down-regulation of NFkB

22
Q

Treatment for hairy cell leukemia

A

Cladribine

23
Q
A

HML II (15 decks)

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