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Flashcards in Hematologic Diseases Deck (76)
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1

Clinical findings of ___ include:

- Doesnt manifest until after 6 months of age

- Weakness, pallor, jaundice

- Abdominal crisis of bowel infarctions

- Organomegaly

- Hand-foot syndrome (children under 2 years)

Sickle Cell Anemia

2

Bony changes in sickle cell anemia are primarily due to _____

ischemia/osteonecrosis

3

Imaging findings of ____ include:

- Fish vertebrae

- "H" vertebrae (Reynolds)

- Hair-on-end skull (uncommon)

- Osteopenia/osteosclerosis

Sickle cell anemia

4

What condition is likely the cause of these findings?

Sickle cell anemia - Hair-on-end

(differential = thalassemia should be first thought)

5

What condition is likely the cause of these findings?

Sickle cell anemia - H vertebra 

(differential = thalassemia should be 2nd thought)

6

What condition is likely the cause of these findings?

Sickle cell anemia - H vertebra & fish shaped

7

What condition is likely the cause of these findings?

Sickle cell anemia - osteosclerosis

(differential = osteopetrosis, padgetts, blastometaphysis)

8

Erlenmeyer flask deformity is associated with osteopetrosis & _____

Sickle cell anemia

9

What condition is likely the cause of these findings?

Sickle cell anemia - hand-foot syndrome

10

What condition is likely the cause of these findings?

Sickle cell anemia - osteomyelitis

(aggressive lesion)

11

What condition is likely the cause of these findings?

Sickle cell anemia - Erlenmeyer flask

12

What condition is likely the cause of these findings?

Sickle cell anemia - multiple bone infarcts

13

The following are soft tissue imaging findings associated with ____:

 

- Gallstones (up to 65%)

- Bowel infarction

- Organomegal

- Auto splenectomy (secondary to infarction and fibrosis)

- Extramedullary hematopoiesis (uncommon)

Sickle cell anemia

14

What condition is likely the cause of these findings?

15

Clinical findings of ____ include:

- Pallor, lethargy, retarded growth

- Organomegaly

- Rodent facies

- Repeated transfusions → hemochromatosis → cardiac failure/death

B-Thhalessemia major

16

What condition is likely the cause of these findings?

B-Thalassemia Major - hair-on-end (most commly occurs in this tradition)

17

What condition is likely the cause of these findings?

B-Thalassemia - hair-on-end

CT

18

What condition is likely the cause of these findings?

B-Thalassemia Major - Honeycomb trabecular pattern

19

What condition is likely the cause of these findings?

B-Thalassemia - Honeycomb trabecular pattern

20

What condition is likely the cause of these findings?

B-Thalassemia Major - Extramedullary hematopoiesis

21

What condition is likely the cause of these findings?

B-Thalassemia Extramedullary Hematopoiesis

22

H-shaped vertebral bodies most common w/ ___ but can be seen with (just less common)

Sickle cell anemia

Thalassemia

23

Most common childhood malignancy (peak age 2-5 years)

Acute childhood leukemia (acute lymphocytic)

24

Imaging findings of ____ include:

- Osteopenia

- Lucent metaphyseal bands

- Periostitis

- Lytic bone lesions

- Splenomegaly

- Chloroma a soft tissue tumor of myeloid tissue (rare)

Acute childhood leukemia

25

What condition is most likely the cause of these findings?

Acute childhood leukemia - lucent metaphyseal bands (other differentials such as rickets)

26

What condition is most likely the cause of these findings?

Acute childhood leukemia - lytic bone lesions (differentials = Ewings, osteomyelitis, etc.)

27

Deficiency of clotting factor VIII = 

Hemophilia A (most common)

28

Deficiency in clotting factor IX =

Hemophila B

29

Clinical manifestations of ____ include:

- Spontaneous bleeding or bleeding from minimal traum

- Bleeding into joint (hemarthrosis) initiates and inflammatory response in the joint

- Joint changes visualized on imaging are a result of this inflammatory process and that is why juvenile idiopathic arthritis is a differential diagnosis

Hemophilia

30

Imaging findings of ___ include:

 

- Overgrowth of epiphyses

- Squared patella•Widened intercondylar notch

- Tibiotalar slant

- Osteopenia

- Increased soft tissue density around joints (due to hemosiderin deposits into synovium)

- Hemophilic pseudotumor (most common in femur and ilium)

Hemophilia