Flashcards in Hematologic Emergencies: Secondary Hemostatic Abnormalities Deck (14):
What are the Secondary Hemostasis Abnormalities?
coagulation factor deficiencies
What can cause acquired coagulation factor deficiencies? (3)
1. Anticoagulant rodenticide toxicity
2. Liver disease
What generation of Anticoagulant rodenticides are these?
What generation of Anticoagulant rodenticides?
What treats the effects of anticoagulant rodenticides? (2)
1. vitamin K
2. coagulation factor administration
How does vitamin K help with clotting?
helps activate clotting factors
What causes these effects on blood clotting?
1. prevents activation of vitamin K and prevents vitamin K from stopping the bleeding
2. toxins antagonize vitamin K activity
3. prevents activation of coagulation factors (intrinsic and extrinsic)
How does liver disease contribute to hemostatic abnormalities?
liver unable to synthesize coagulation factors
What is DIC?
a condition in which coagulation is increased
What does DIC cause? (2)
1. clots are formed throughout the circulatory system
2. hemorrhage due to consumption of coagulation factors and platelets
What causes DIC?
Inflammatory mediators that cause tissue factor expression during systemic inflammatory response syndrome (SIRS)
What are these symptoms of?
3. Massive tissue trauma
What do these things cause ?
3. Heat stroke
4. Crushing injury