Hematologic Emergencies: Secondary Hemostatic Abnormalities Flashcards Preview

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Flashcards in Hematologic Emergencies: Secondary Hemostatic Abnormalities Deck (14):
1

What are the Secondary Hemostasis Abnormalities?

coagulation factor deficiencies

2

What can cause acquired coagulation factor deficiencies? (3)

1. Anticoagulant rodenticide toxicity
2. Liver disease
3. DIC

3

What generation of Anticoagulant rodenticides are these?
1. Warfarin
2. Inandione

1st generation

4

What generation of Anticoagulant rodenticides?
1. Brodifacoum
2. Bromdiolone

2nd generation

5

What treats the effects of anticoagulant rodenticides? (2)

1. vitamin K
2. coagulation factor administration

6

How does vitamin K help with clotting?

helps activate clotting factors

7

What causes these effects on blood clotting?
1. prevents activation of vitamin K and prevents vitamin K from stopping the bleeding
2. toxins antagonize vitamin K activity
3. prevents activation of coagulation factors (intrinsic and extrinsic)

anticoagulant rodenticides

8

How does liver disease contribute to hemostatic abnormalities?

liver unable to synthesize coagulation factors

9

What is DIC?

a condition in which coagulation is increased

10

What does DIC cause? (2)

1. clots are formed throughout the circulatory system
2. hemorrhage due to consumption of coagulation factors and platelets

11

What causes DIC?

Inflammatory mediators that cause tissue factor expression during systemic inflammatory response syndrome (SIRS)

12

What are these symptoms of?
1. Sepsis
2. Neoplasia
3. Massive tissue trauma
4. Ischemia

DIC

13

What do these things cause ?
1. Shock
2. GDV
3. Heat stroke
4. Crushing injury
5. Pancreatitis

ischemia

14

What are these tests for?
1. PT (prolonged)
2. aPTT (prolonged)
3. ACT (prolonged)
4. Fibrinogen (low)
5. FDP (increased)

DIC