Hematology 2

Question 1

What are appropriate alternative anticoagulants for a pt w/HIT?

Answer 1

Direct thrombin inhibitors: argatroban or lepirudin

Question 2

_______ is characterized by thrombocytopenia, fever, microangiopathic hemolytic anemia, acute neurological Sx, and renal disease.

Answer 2

TTP

Question 3

_______ is characterized by thrombocytopenia, microangiopathic hemolytic anemia, and renal disease.

Answer 3

HUS

Question 4

What Sx do TTP and HUS share?

Answer 4

Thrombocytopenia, microangiopathic hemolytic anemia, and renal disease.

Question 5

What Are the 2 features of TTP that aren’t present in HUS?

Answer 5

Acute neurologic Sx and fever.

Question 6

Describe the characteristic findings of ITP.

Answer 6

Completely normal except for severe thrombocytopenia and purpura. (No fever, decreased WBC cts, anemia, neurologic Sx.)

Question 7

Which component of oral contraceptive pills increases the Rick of thrombosis?

Answer 7

Estrogen

Question 8

What kind of oral contraceptives should women with thrombophilias use?

Answer 8

Progestin only

Question 9

Why does Factor V Leiden mutation predispose to thrombosis?

Answer 9

Factor V is required to activate Protein C.