Hematology

Question 1

What are the 2 amin methods by which red cell mass may be reduced in polycythemia vera?

Answer 1

phlebotomy and hydroxyurea

Question 2

How is myelodysplastic syndrome defined?

Answer 2

cytopenia of at least one lineage

Question 3

Total Iron Binding Capacity and _______ are the same.

Answer 3

transferrin

Question 4

Which iron study represents the amount of iron stored in the bone marrow?

Answer 4

ferritin

Question 5

What are the levels of serum iron, ferritin, and TIBC in iron deficiency anemia?

Answer 5

Fe: low
ferritin: low
TIBC: high

Question 6

What are the levels of serum iron, ferritin, and TIBC in anemia of chronic disease?

Answer 6

Fe: low
ferritin: high
TIBC: low

Question 7

What is the preferred therapy for aplastic anemia?

Answer 7

anti-thymocyte immune globulin and cyclosporine

Question 8

What is myelophthisis?

Answer 8

displacement of the bone marrow into the peripheral blood d/t fibrosis,granulomas, or tumors (including myeloproliferative disease).

Question 9

What do high serum LDH and indirect bilirubin levels indicate?

Answer 9

hemolysis

Question 10

What is the difference between B6 and B12 deficiency in terms of homocysteine and methylmalonic acid levels?

Answer 10

B6 def: only increased homocysteine

B12 def: increased homocysteine and methylmalonic acid

Question 11

What type of RBCs are typically found in the peripheral blood smear in autoimmune hemolytic anemia?

Answer 11

microspherocytes

Question 12

What is typical of the the peripheral blood smear in Fe def anemia?

Answer 12

microcytic hypochromic RBCs of various shapes and sizes

Question 13

WHat are the results of serum electrophoresis in α-thalassemia?

Answer 13

normal

Question 14

How are the RBC counts in thalassemias?

Answer 14

normal to high

Question 15

Anemia of chronic disease causes the release of IL-6, which in turn causes the release of _______.

Answer 15

hepcidin

Question 16

How does hepcidin mediate anemia of chronic disease?

Answer 16

decreases Fe absorption in the gut and release from MΦ

Question 17

What kind of Ab’s are typically found in autoimmune hemolytic anemia (AIHA)?

Answer 17

anti-Rh warm-Ab’s (IgG)

Question 18

What is the best initial therapy for AIHA?

Answer 18

corticosteroids

Question 19

What are the 2 major indications for EPO administration?

Answer 19

chronic kidney disease and myelodysplasia

Question 20

What is the pathophysiological mechanism of acquired factor VIII deficiency?

Answer 20

production of a Factor VIII inhibitor

Question 21

What kinds of disease most commonly cause acquired factor VIII deficiency (give 3)?

Answer 21

autoimmune, malignancy (esp. lymphoma), and post-partum

Question 22

How does vWF deficiency affect coagulation studies?

Answer 22

prolonged bleeding time and PTT