Hematology: Malignant Myeloproliferative DIsorders

Question 1

with dysgranulopoiesis and dysmegakaryopoiesis

Answer 1

RAEB

Question 2

RARS is similar to RA except

Answer 2

RARS have phatologic ringed sideroblasts

Question 3

clonal hematopoietic neoplasms characterized by **cytopenias **due to ineffective hematopoiesis and increased apoptosis

Answer 3

Myelodysplastic Syndromes

Question 4

the three abnormalities found in PB and BM in MDSs

Answer 4

1. dyserythropoiesis
2. dysgranulopoiesis
3. dysmegakaryocytopoiesis

Question 5

AML subgroup that stains negatively with MPO and SBB

Answer 5

M0

Question 6

neutropinia, anemia, and thrombocytopenia is a lab finding in _____?

Answer 6

Acute Myeloid Leukemia

Question 7

unregulated proliferation of the myeloid stem cell

Answer 7

AML
Acute Myeloid Leukemia

Question 8

FAB classification of DMPS where anemia is not responsive to therapy

Answer 8

Refractory Anemia

Question 9

chromosome abnormality is t(15-17)

Answer 9

M3 (APL)

Question 10

DMPS where there is impaired hemoglobinization of RBC

Answer 10

RARS

Question 11

highest degree of skin and tounge disease involvement, bcs of migration of leukocytes

Answer 11

M3 (APL)

Question 12

DMPS where there is dyspoiesis, presents with leukocytosis (WBC >100x109/L)

Answer 12

CMML (Chronic Myelomonocytic Leukemia)

Question 13

in the laboratory findings of this anemia, absolute reticulocytopenia is found

Answer 13

RA/RC

Question 14

also called Naegeli leukemia

predominance of myeloblast nds myelocyte

Answer 14

M4 (AMML)

Question 15

Also known as* Schilling’s Leukemia*

Answer 15

M5 (AMoL)

Question 16

Megakaryocytic Leukemia is only positive in what cytochemical stain?

Answer 16

ANAE

Question 17

DMPS where there is presence or absence of auer rods

Answer 17

RAEBIT

Question 18

Presents with pancytopenia and bleeding

Answer 18

M7 (AMegL)

Question 19

2 subgroups of AML that comprises 30% relative frequency

Answer 19

M2, M4

Question 20

AML where predominant cell is poorly differentiated myeloblast without granulations

Answer 20

M1 (Myeloblastic anemia with minimal maturation

Question 21

Auer rods are predominantly seen in

Answer 21

myelobasts or promyelocytes

Question 22

High risk of developing into AML

Answer 22

RAEBIT

Question 23

the mildest form of DMPs

Answer 23

RA/RC

Question 24

In RAEB and M2, how are they differentiated

Answer 24

M0 have auer rods

Question 25

derivative of azurophilic granules, stains positively for MPO, SBB, and CAE

Answer 25

Auer rods

Question 26

Chromosome abnormality is **t(15-17)** and predominantly associated with** DIC** (thromboplastin)

Answer 26

M3 (APL)

Question 27

gum hypertrophy and infiltration, rectal ulceration, skin involvement

Answer 27

M4 (AMML)

Question 28

MPO and SBB stain positive in M0? True or False.

Answer 28

False.

Question 29

the one MDS that usually presents with leukocytosis

Answer 29

CMML (Chronic Myelomonocytic Leukemia)

Question 30

associated with chromosome abnormality t(8,21)

Answer 30

M2 (Myeloblastic Leukemia with maturation)

Question 31

anemia is refractory, no dysgranulopoiesis, no dysmegakaryopoiesis

Answer 31

RA/RC

Question 32

Laboratory findings include Philadelphia chromosome; normocytic normochronic anemia

Answer 32

Chronic Myelogenous Leukemia (CML)

Question 33

Philadelphia chromosome is a translocation in what two chromosome

Answer 33

t(9,22)

Question 34

Proliferation of granulocytic, erythrocytic, and megakarocytic series seen in spleen, liver, and lymph nodes also has presence of teardrop RBC, blood picture (nRBC+immature WBC+ab platelets)

Answer 34

Primary Myelofibrosis

Question 35

Proliferation of megakaryocytes; increase in platelet mass w/out accompanying significant erythrocytosis. Many giant and bizarre forms of platelets. platelet count >600 x 109/L

Answer 35

Essential Thrombocytopenia

Question 36

Rarest of the chronic MPDs, high LAP score

Answer 36

Chronic Neutrophilic Leukemia

Question 37

mildest form of DMPS

Answer 37

RA/RC

Question 38

dimorphic anemia (hypochromic microcytes and oval macrocytes)

Answer 38

RARS

Question 39

with dysgranulopoiesis and dysmegakaryopoiesis

Answer 39

RAEB

Question 40

the one MDS that usually presents with leukocytosis

Answer 40

CMML

Question 41

presence/absence of auer rods

Answer 41

RAEBIT

Question 42

linear, spindle-shaped, red-purple inclusions

Answer 42

Auer rods

Question 43

Auer rods seen in

Answer 43

myeloblasts promyelocytes

Question 44

frequently assoc w DIC

Answer 44

M3 (APL)

Question 45

FAGGOT CELLS

Answer 45

M3

Question 46

erythrocytes have nRBCs and HJ bodies leukomoid reax vs cml

Answer 46

cml

Question 47

increase in all cell line

Answer 47

PV