IS: Diseases and Sero tests

Question 1

are self-replicating extrachromosomal dna molecules that are located in the bacteria’s cytoplasm and contain limited number of genetic elements

Answer 1

Plasmid

Question 2

Found on the cell wall of gram - bacteria

Answer 2

Lipopolysaccharide

Question 3

Function in the attachment of bacteria to host cell

Answer 3

F or sex pili

Question 4

enhance ability of S. pyogenes pili to attach to host cell particularly to fibronectin

Answer 4

F protein

Question 5

limits deposition of C3 on the bacterial surface

Answer 5

M protein

Question 6

Proteins excreted by bacterial cells as they metabolize during course of strep infections

Answer 6

exoantigens/exotoxins

Question 7

strep enzyme that promotes fibrinolytic activity by converting plasminogen to plasmin

Answer 7

streptokinase

Question 8

enhances spread of streptococcus through connective tissue

Answer 8

hyaluronidase

Question 9

inactive in the oxidized form and can cause lysis of wbc and rbc in its reduced state

Answer 9

Streptolysin 0

Question 10

MW of streptolysin O

Answer 10

70 000 daltons

Question 11

produces surface hemolysis on BAP and is non antifenic with 2800 MW

Answer 11

Streptolysin S

Question 12

result of pharyngeal infection; URTI with rash due to erythrogenic toxin

Answer 12

Scarlet Fever

Question 13

very red and swollen and there is well-defined border btwn normal and infected skin

Answer 13

Erysipelas/St. Anthony’s fire

Question 14

skin infection that invades muscles of extremities or trunk

exotoxins deep in fascia result in ischemia, tissue necrosis, and sepsis

Answer 14

necrotizing fasciitis

Question 15

main damaging sequelae of group a strep

Answer 15

glumerulonephritis
Acute RHF

Question 16

strep is plated on

Answer 16

blood agar

Question 17

ASO titer for children in ASOT testing

Answer 17

360 Todd units

Question 18

positive result in anti-dnase test

Answer 18

green color persists

Question 19

MOT of H. pylori

Answer 19

fecal-oral, oral-oral

Question 20

urea is broken down to what in urea breath test

Answer 20

ammonia and bicarbonate

Question 21

used to determine success of therapy in h. pylori

Answer 21

rapid EIA

Question 22

best for initial screening method

Answer 22

anti H. pylori detection/ ELISA

Question 23

mulberry//fried egg appearance in culture

Answer 23

M. pneumoniae

Question 24

2 syndromes caused by M. pneumoniae

Answer 24

Reynaud’s syndrome
Stevens-Johnson syndrome

Question 25

rash appear first on trunk and later to extremities

Answer 25

Thypus group

Question 26

Rocy mountain spotted fever is caused by

Answer 26

Rickettsia ricketsii

Question 27

Rocky mountain fever is transmitted by

Answer 27

american dog tick (D. variabilis), wood tick (D. andersoni) brown dog tick (R. sanguineus)

Question 28

target cell of rocky mountain fever

Answer 28

vascular endothelium

Question 29

method of choice for rickettsial infection

Answer 29

serodiagnosis

Question 30

gold standard in derecting rickettsial antibodies

Answer 30

IFA micro IF

Question 31

long slendel helically coiled microaerophilic bacteria that has periplasmig flagella and corkscrew movement

Answer 31

spirochetes

Question 32

pinta is caused by

Answer 32

T. carateum

Question 33

t. pallidum s. pallidum is best observed in

Answer 33

DFM

Question 34

evolves from macule to papula and into ulcer firm painless non itchy skin ulceration

Answer 34

chancre

Question 35

patches that become maculopapular forms white flat whitish wart like lesions

Answer 35

condylomata lata

Question 36

tabes dorsalis in tertiary stage of syphilis means

Answer 36

general paralysis

Question 37

chronic skin and bone disease of tropics with fambresia lesions

Answer 37

yaws

Question 39

buba causative agent

Answer 39

T. pallidum s. pertenue

Question 40

this test reacts with cardiolipin

Answer 40

non trep test

Question 41

false positive in non trep test occurs in diseases such as

Answer 41

hepa, im, measles

Question 42

VDRL,RPR,ISR are examples of

Answer 42

non trep test

Question 43

only sero test approved for diagnosing neurosyphilis

Answer 43

vdrl

Question 44

removes anti-complement property of cardiolipin

Answer 44

lecithin

Question 45

preservative used in rpr

Answer 45

thimerosal

Question 46

trep test that is test of choice for neurosyphilis and rule out false pos result

Answer 46

TPI test

Question 47

uses reiter strain and nichols strain

Answer 47

FTA-ABS

Question 48

diag of neurosyphilis in aids ptx

Answer 48

pcr

Question 49

microhemagglutinaton uses

Answer 49

formalinized tanned sheep rbc

Question 50

hatta and tpha

Answer 50

gluteraldehyde stabilized sheep rbc

Question 51

pos result for this is lattice-like structure covering surface of well, used to detect primary syphilis and uses gelatin

Answer 51

TP-PA

Question 52

5-30 um long, 0.2-0.5 um wide and contain 7-22 periplasmig flagella

Answer 52

Borrelia spp

Question 53

vector-borne multisystem illness involving skin, nervous system heart and joints

Answer 53

lyme disease

Question 54

causative agent for lyme disease

Answer 54

borrelia burgdorferi sensu stricto

Question 55

ixode in west us

Answer 55

i. pacificus

Question 56

main reservoir host of borrelia

Answer 56

white footed mouse / peromyscus leucopus

Question 57

bull's eye lesion

Answer 57

erythema chronicum migrans or ECM in stage 1 lyme disease

Question 58

arthritis, late neuroborreliosis

Answer 58

late lyme disease/stage 3