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Hematology > Hematology Week 1: Secondary Homeostasis > Flashcards

Hematology Week 1: Secondary Homeostasis Flashcards

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1
Q

Secondary Hemostasis AKA

A

Coagulation

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2
Q

Primary hemostasis

A
  • platelet plug formation platelets adhere to collagen in the subendothelium and become activated
  • forms surface for coagulation reactions
  • localizes fibrin formation at the injury site
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3
Q

Secondary Hemostasis

A

Coagulation formation

Fibrin Clot formation

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4
Q

Overall system of Vascular injury

A

1st vasoconstriction

2nd exposure of sub-endothelial (collagen)

3rd exposure of tissue factor

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5
Q

Key points of secondary hemostasis

A
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6
Q

Without platelets

A

coagulation reactions cannot occur

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7
Q

Coagulation factors

A

Factor VI was removed because it is the active form of factor V

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8
Q

Textbook representation of coagulation

A
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9
Q

Physiologic pathway of coagulation

A
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10
Q

FVIIa activates

A

FX

FIX

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11
Q

FXI activates

A

FIX

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12
Q

Activators of FIX

A

FVIIa

FXI

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13
Q

FIX in complex with FVIII Activates

A

FX

massive amplification

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14
Q

FXa in complex with FV activates

A

Prothrombin to Thrombin

massive amplification

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15
Q

Integrated Mass Activation Process of Hemostasis: First Minute & Second Minute

A
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16
Q

Integrated Mass Activation Process of Hemostasis: 2-20 minutes and Hours-days

A
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17
Q

No factor XIII

A

No crosslinking of fibrin by factor XIII so will clot fine but then the clot will break open

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18
Q

Clinical Signs Associated with bleeding

Platelet and vWD Defects

7 listed

A
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19
Q

Clinical Signs Associated with bleeding

Coagulation Defects

6 listed

A
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20
Q

Identify

A

Hematoma

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21
Q

Identify

A

Missing FXIII bleeds into muscle and bone space

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22
Q

Identify

A

bleeding into knees

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23
Q

Identify

A

Severe knee bleeding

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24
Q

Identify

A

knee fusion from knee bleeding and not walking or moving it

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25
Identify
bleeding in the abdomen's surface
26
Coagulation Lab Values
27
Pre-Analytical Variables
How the blood is collected, processed and stored can produce erroneous results
28
Laboratory tests of coagulation 7 listed
29
Coagulation specific Tests 2 listed
* Specific Factor Assays * Dependent on abnormal screening results
30
Global Clotting Assays based on PT and PTT
31
PT AKA
Pro Time
32
PT is often used for?
Commonly used to Monitor coumadin and warfarin
33
Procoagulant Proteins Vitamin K Dependent
* Prothrombin * Factor 10 * Factor 7 * Factor 9
34
Anticoagulant proteins vitamin K-dependent
* Protein C * Protein S
35
Vitamin K function in dependent coagulation proteins
Vitamin K carboxylates coagulation proteins posttranslationally to allow that molecule to bind to a phospholipid surface in the presence of Ca2+ Warfarin makes them non-carboxylated Vitamin K deficiency makes non-carboxylated
36
Warfarin
Must monitor once a month
37
INR
International Normalized Ratio
38
PTT AKA
Partial Thromboplastin Time
39
PTT uses
40
Mixing Studies
mixing patient plasma with normal plasma mix it want to see if it corrects or fails to correct and prolongs
41
PTT Mixing Studies Interpretations
42
Coagulation Abnormalities Disorders
43
Coagulation Levels
44
Hemophilia
45
Hemophilia Genetics
Both hemophilia A and B are on X chromosome
46
Factor 8 Deficiency AKA
Hemophilia A
47
Factor 8 Deficiency
48
Factor 9 Deficiency AKA
Hemophilia B
49
Factor 9 Deficiency
50
Clinical Classification of Hemophilia
51
Factor 11 Deficiency AKA
Hemophilia C
52
Hemophilia C common in this ethnic group
ashkenazi jewish
53
Factor 11 Deficiency
54
Laboratory findings of Hemophilia
55
Genetics of Hemophilia
56
Causes of death of hemophiliacs
57
Inhibitor Formation in treatment of Hemophilia
antibody to Factor 8
58
Inhibitor testing in Hemophilia
59
Complications of hemophilia
60
Treatment of Hemophilia
61
New treatments for hemophilia
62
New treatments for hemophilia B
63
Coagulation in liver disease Etiology
Viral Cirrhosis Liver Transplant processes
64
Decreased factor synthesis in liver disease and associated major bleeding risks
65
Hemostatic system in newborns
66
Hemostatic system in Children
67
Hemorrhagic Disease of the newborn
sometimes in home births or vitamin k deficient
68
69
Mechanism of hemorrhagic disease of the newborn 4 listed
70
REMEMBER
71
Most disease processes are associated with hemostatic complications

Hematology (26 decks)

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