Hematopoeisis

Question 0

Predominant hemoglobin at birth?

Answer 0

Hgb F

*80%

Question 1

The pluripotential stem cell is stimulated by: (3)

inhibited by: (1)

Answer 1

Stimulated by:
Phytohemagglutin
Cyclophosphamide
Concanavalin A

Inhibited by:
Hydroxyurea

Question 2

Stage of Granulopoeisis where in synthesis of peroxidase-rich primary granules BEGINS and ENDS.

Answer 2

Promyelocyte

Question 3

Stage of Granulopoeisis that begins to form secondary granules; last stage to undergo mitosis.

Answer 3

Myelocyte

Question 4

Stage of Granulopoeisis also known as Juvenile cell. Kidney/bean/peanut shape.

Answer 4

Metamyelocyte

*indentation of nucleus is <half of its width

Question 5

Mitotic pool of Granulopoeisis.

Answer 5

Myeloblast -> Myelocyte
DIVIDING STAGES; 2-3 days; 4-5 cell divisions.

Maturation pool:
Metamyelocyte -> mature; 5-7 days; NO DIVISIONS

Question 6

Test for PHAGOCYTOSIS.

Answer 6

1. Boyden Micropore Filter Technique
2. Rebuck Skin Window Technique
3. Nitroblue Tetrazolium Test

Question 7

Eosinophils damage what stage of helminths.

Answer 7

Larval stage

Question 8

Neutrophilia is seen in: (4)

Answer 8

Infection
Inflammation
Malignancy
Lithium toxicity

Question 9

Neutropenia is seen in:

Answer 9

Typhoid fever
Paratyphoid
Brucellosis
Measles
Yellow fever
Infectious hepatitis
Rubella
Neonatal isoimmune neutropenia

Question 10

Decreased in the presence of glucocorticoids.

Answer 10

Eosinophils
Basophils
Monocytes

Question 11

Impaired directional and random motility of phagocytes.

Answer 11

Lazy leukocyte syndrome

*JOB’s syndrome-> impaired directional motility ONLY.

Question 12

Site of choice for BONE MARROW preperation and evaluation.

Answer 12

Posterior iliac crest

*collection-> trephine biopsy and aspiration