Hemoglobin

Question 0

Anisocytosis, red cell size variation is measured by:

Answer 0

Red cell Distribution Width /RDW

*shape variation: POIKILOCYTOSIS

Question 1

Cyanmethemoglobin Method measures all forms of Hb except.

Answer 1

SULFHEMOGLOBIN

Question 2

Red cells withOUT central pallor; due to spectrin deficiency

Answer 2

Spherocyte

Question 3

Sea Urchin cells; Burr cells; sometimes reffered to as crenated red cells.

Answer 3

Echinocytes

• seen in UREMIA
• reversible to original shape

Question 4

A slit like central pallor, seen in ALCOHOLISM
RH NULL SYNDROME
H. STOMATOCYTOSIS

Answer 4

Stomatocytes / mouth cell

*membrane defect resulting to increased SODIUM and decreased POTASSIUM content.

Question 5

Schistocyte is seen in: (3)

Answer 5

Microangiopathic hemolytic anemia/ MAHA
Traumatic Hemolytic anemia
Severe burns

Question 6

A scistocyte with horn- like projections, blister cell.

Answer 6

Keratocytes

Question 7

Dacrocytes/ tear drop cells is seen in: (5M)

Answer 7

Myelofribrosis with Myeloid Metaplasia
Myelopthisic anemia
Metastatic tumor

Question 8

Most common hemoglobin variant; due to glu to val substitution at 6th position of beta chain.

Answer 8

Sickle cell anemia / Hgb S

Question 9

Due to glu-lys substitution at 6th position of beta chain; SECOND most common variant of hgb.

Answer 9

Hgb C

Question 10

Known as pocketbook cells ; Washington monument.

Answer 10

Hgb SC

Question 11

Due to glu-lys substitution at 26th position of beta chain, THIRD most common variant of Hgb.

Answer 11

Hgb E

Question 12

Also known as Hgb C Georgetown.

Answer 12

Hgb C Harlem

Question 13

Asp-lys substitution at 68th position of ALPHA chain.

Only significant alpha chain variant.

Answer 13

Hgb G Philadelphia

Question 14

Amino acid DELETION at positions 91-95 of the beta chain.

Answer 14

Hgb Gun Hill

‘Gone’-deletions

Question 15

This is due to auto-anti-P (Donath-Landsteiner)

Answer 15

Paroxysmal Cold Hemoglobinuria