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Flashcards in Hemoglobin Deck (16)
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Cyanmethemoglobin Method measures all forms of Hb except.

SULFHEMOGLOBIN

1

Anisocytosis, red cell size variation is measured by:

Red cell Distribution Width /RDW

*shape variation: POIKILOCYTOSIS

2

Red cells withOUT central pallor; due to spectrin deficiency

Spherocyte

3

Sea Urchin cells; Burr cells; sometimes reffered to as crenated red cells.

Echinocytes

*seen in UREMIA
*reversible to original shape

4

A slit like central pallor, seen in ALCOHOLISM
RH NULL SYNDROME
H. STOMATOCYTOSIS

Stomatocytes / mouth cell

*membrane defect resulting to increased SODIUM and decreased POTASSIUM content.

5

Schistocyte is seen in: (3)

Microangiopathic hemolytic anemia/ MAHA
Traumatic Hemolytic anemia
Severe burns

6

A scistocyte with horn- like projections, blister cell.

Keratocytes

7

Dacrocytes/ tear drop cells is seen in: (5M)

Myelofribrosis with Myeloid Metaplasia
Myelopthisic anemia
Metastatic tumor

8

Most common hemoglobin variant; due to glu to val substitution at 6th position of beta chain.

Sickle cell anemia / Hgb S

9

Due to glu-lys substitution at 6th position of beta chain; SECOND most common variant of hgb.

Hgb C

10

Known as pocketbook cells ; Washington monument.

Hgb SC

11

Due to glu-lys substitution at 26th position of beta chain, THIRD most common variant of Hgb.

Hgb E

12

Also known as Hgb C Georgetown.

Hgb C Harlem

13

Asp-lys substitution at 68th position of ALPHA chain.

Only significant alpha chain variant.

Hgb G Philadelphia

14

Amino acid DELETION at positions 91-95 of the beta chain.

Hgb Gun Hill
('Gone'-deletions)

15

This is due to auto-anti-P (Donath-Landsteiner)

Paroxysmal Cold Hemoglobinuria