HEME

Question 0

PRO-Coagulants (2)

What does each do?

Answer 0

• a2 Antiplasmin

- a2 Microglobulin

Question 1

Ablation of BM before BM Transplant (3)

Answer 1

• Busulfan
• Hydroxyurea
• Imatinib

Question 2

ANTI-Coagulants (3)

What does each do?

Answer 2

• tPA
• Heparin
• Warfarin

Question 3

CHRONIC Anticoagulation +
Prevention of Stroke + Venous TE

(2)?

Answer 3

• Warfarin

- Factor 10A Inhibitors (-ban: Apixaban + Rivaroxaban)

Question 4

Anticoagulants for Heparin-Induced Thrombocytopenia (HIT) (2)

Answer 4

(Hirudin derivatives. Alternatives to Heparin.)

• Argatroban
• Bivalirudin

Question 5

Intermittent Claudication (Drug Class, incl 2)

Answer 5

Phosphodiesterase III Inhibitors:

• Cilostazol
• Dipyridamole

Question 6

Von Willebrand’s Disease

Answer 6

DDAVP = Desmopressin (release of vwf stored in endothelium)

Question 7

Lead Poisoning (2: Kids vs Adults)

Answer 7

• 1st for Kids = Succimer

- 1st for Adults = Dimercaprol + EDTA

Question 8

Angina PROPHYLAXIS (Drug Class, incl 2)

Answer 8

Phosphodiesterase III Inhibitors:

• Cilostazol
• Dipyridamole

Question 9

UNSTABLE Angina (Drug Class, incl 3)

Answer 9

GP 2B/3A Inhibitors:

• Abciximab
• Eptifibatide
• Tirofiban

Question 10

Microcytic Sideroblastic Anemia

Answer 10

Vit B6 = Pyridoxine

Question 11

Leukemias + Lymphomas

7: last 4 = groups for solid tumors too

Answer 11

• ara-C
• MTX
• 6-MP
• -famide
• -poside
• -rubicin
• Vin-

Question 12

M3 AML

Answer 12

TRANS-Retinoic Acid = Vit A (induces myeloblast differentiation)

Question 13

CLL (3)

Answer 13

• Prednisone
• Prednisolone
• Alymtuzumab

Question 14

CML (3)

Answer 14

• Busulfan
• Hydroxyurea
• Imatinib (inhib bcr-abl tyrosine kinase)

Question 15

Hodgkin’s Lymphoma

Answer 15

Bleomycin

Question 16

NHL

Answer 16

• Prednisone

- Prednisolone

Question 17

B-Cell NHL

Answer 17

Rituximab

Question 18

Paroxysmal Nocturnal Hematuria

Answer 18

Eculizumab

Question 19

Chronic Granulomatous Dz

Answer 19

y-Interferon

Question 20

Sickle Cell Dz

Answer 20

Hydroxyurea (↑HbF)

Question 21

Bleomycin (2)

Answer 21

USES:

• Hodgkin Lymphoma
• Testicular Cancer

Question 22

Busulfan (2)

Answer 22

USES:

• BM ablation before transplantation
• CML

Question 23

Dactinomycin (3 childhood tumors)

*THINK: “Children ACT out” *

Answer 23

USES: Children

• Ewing Sarcoma
• Rhabdomyosarcoma
• Wilms tumor

Question 24

Dano- + Doxorubicin (2 large categories)

Answer 24

USES: - Leukemias + Lymphomas - Solid tumors

Question 25

Hydroxyurea Mech (2 steps), Uses (3)?

Answer 25

MECH: Inhib ribonucleotide reductase ->↓DNA synthesis (S-phase specific) USES: - CML - Melanoma - Sickle Cell Dz

Question 26

Imatinib Mech (2 genes), Uses (2)?

Answer 26

MECH: Tyrosine Kinase inhibitor of: - BCR-ABL (CML) - C-Kit (GI stromal tumors) USES: - CML - GI stromal tumors

Question 27

Nitrosoureas: -mustine + Streptozocin

Answer 27

Brain tumors *Cross BBB*

Question 28

Prednisone + Prednisolone (3, incl 2 cancer chemo)

Answer 28

USES: *MC glucocorticoids used in cancer chemo* - CLL - NHL - Immunosuppression

Question 29

Vemurafenib Mech, Use?

Answer 29

MECH = Inhib of BRAF oncogene (in BRAF Melanoma) USES: - Metastatic Melanoma