IMMUNO

Question 1

Immuno Drugs ~GENERAL~

Uses (4), Mech?

Answer 1

USES:

• Prevention of transplant rejection
• Autoimmune disorders (ie HLA-B27: “CRAP”)
• Infl conditions
• Cancer therapy

MECH = Blocks production of IL-2 and its receptor.

Question 2

Autoimmune Dz INCL Glomerulonephritis + Hemolytic Anemia

Answer 2

Azathioprine

Question 3

HLA-B27 “CRAP”: Crohn’s, RA, Ankylosing Spondylitis, Psoriatic Arthritis

Answer 3

INFLiximab

Question 4

HLA-B27 “Less CRAP = CRP”: Crohn’s, RA, Psoriatic Arthritis (2)

Answer 4

• Adalimumab

- Etanercept

Question 5

Cardiac Ischemia + MI

Answer 5

Abciximab / EptiFIBAtide / TiroFIBAn

Question 6

Severe Asthma (additional line of treatment)

Answer 6

Omalizumab

Question 7

Osteoporosis

Target?

Answer 7

Denosumab (THINK: “Density” and “os”)

TARGET = RANKL

Question 8

Thrombocytopenia (3)

Answer 8

• Thrombopoietin
• Eltrombopah / Romiplostim
• Oprelvekin (IL-11 recombinant cytokine)

Question 9

Recovery of BM (2)

Answer 9

IL-3 recombinant cytokines:

• Filgrastim (granulocyte colony-stim factor)
• Sargramostim (granulocyte + macrophage colony-stim factor)

Question 10

Paroxysmal Nocturnal Hematuria

Answer 10

Eculizumab

Question 11

Cyclosporine

Mech (4 steps)?

Answer 11

MECH:
Binds to cyclophilins ->
Inhibits calcineurin -> 
Blocks activation of T cells ->
Prevents production of IL-2 and its receptor.

Question 12

Tacrolimus

Mech (1 difference from Cyclosporine Mech)?

Answer 12

MECH:

Binds to FK-binding protein = FK506

Question 13

Sirolimus / Rapamycin

Mech (1 difference from Tacrolimus Mech)?

Answer 13

MECH:
Inhibits mTOR

THINK: SEEroLIMus: “Sees” (recognizes) IL-2 -> “Limits” T cell prolif.

Question 13

Muromonab-CD3 / OKT3

• THINK: MORONonab: “3 stooges are morons”. *

Target, Mech (2 steps)?

Answer 13

TARGET = CD3 on T cells

MECH = Antibody to CD3 on T cells -> Blocks T cell transduction

Question 14

Daclizumab / Basiliximab

Target, Mech, Use?

Answer 14

TARGET = IL-2 receptor

MECH = Ab against IL-2 receptor

USE:
- Kidney transplants

Question 15

TNF-a / Cachexin Targets (4)

Answer 15

• Infliximab
• Adalimumab
• Etanercept
• Thalidamide

Question 16

Abciximab / EptiFIBAtide / TiroFIBAn

Target, Uses (2)?

Answer 16

TARGET = Glycoprotein IIb / IIIa (glycoprotein found on platelets => role in clotting cascade)

USES:

• Prevention of cardiac ischemia
• MI

Question 17

Trastuzumab / Herceptin

Target, Uses (2)?

Answer 17

TARGET = erb-b2 / her-2 (protooncogene)

USES:

• Her-2-overexpressing Breast Cancer
• Gastric Cancer

Question 18

Rituximab

Target, Use?

Answer 18

TARGET = CD20 (CD20 found on most B cell neoplasms)

USES:
- B cell NHL

Question 19

Omalizumab

Target, Mech, Use?

Answer 19

TARGET = IgE

MECH = Prevents IgE binding to FCERI

USES:
- Severe Asthma

Question 20

Bevacizumab / Ranibizumab

*THINK: Beva and Rani *

Target, Mech, Uses (2)?

Answer 20

TARGET = VEGF

MECH = Inhibition of Angiogenesis

USES:

• Solid tumors
• Age-related Macular Degeneration

Question 21

Eculizumab

Target, Use?

Answer 21

TARGET = C5

USES:
- Paroxysmal Nocturnal Hematuria

Question 22

Natalizumab

THINK: Many “A”s

Target, Uses (2)?

Answer 22

TARGET = A4 Integrin

USES:

• Crohn’s
• MS

Question 23

Palivisumab

Target, Use?

Answer 23

TARGET = RSV F Protein

USE = RSV prophylaxis

Question 24

ALYMtuzumab Target, Use?

Answer 24

TARGET = CD52 USE = Chronic LYMphocytic Leukemia

Question 25

CeTUXimab Target, Uses (2)?

Answer 25

TARGET = EGFR USES: - Stage 4 CRC - Head + Neck Cancers

Question 28

VemaRAFenib Target, Use?

Answer 28

TARGET = B-RAF Kinase USE = Metastatic Melanoma

Question 29

Mycophenolate Target, Mech (2 steps), Uses (2)?

Answer 29

TARGET = Inosine Monophosphate Dehydrogenase MECH: Prevents production of Guanine -> Stops B + T cell prolif. USES: ( - Transplants - ) - Lupus Glomerulonephritis

Question 30

Interferon-a Uses (6)?

Answer 30

USES: - Hepatitis B + C (Chronic) - Kaposi Sarcoma - Hairy Cell Leukemia - Malignant Melanoma - Renal Cell Carcinoma - Condyloma Acuminatum

Question 31

Interferon-b Use?

Answer 31

USE = MS

Question 32

Interferon-y Use?

Answer 32

USE = Chronic Granulomatous Dz | NADPH Oxidase def

Question 33

Thalidamide / Contergan Target, Uses (2)?

Answer 33

TARGET = TNF-a | USES: - Immunosuppression - * - Anti-angiogenic

Question 34

Aldesleukin: IL-2 recombinant cytokine *THINK: Al"dos"leukin* Uses (2)?

Answer 34

USES: - Metastatic Melanoma - Renal Cell Carcinoma