heme-onc

Question 1

poikilocytosis

Answer 1

RBCs of differing shapes

Question 2

life span of platelets

Answer 2

8-10 days

Question 3

leads to petechiae

Answer 3

thrombocytopenia

Question 4

vWF receptor

Answer 4

GpIb on platelets

Question 5

fibrinogen receptor

Answer 5

GpIIb/IIIa on platelets

Question 6

neutrophils with more than 4 lobes indicate

Answer 6

b12/folate decieciency

Question 7

increase in band cells can indicate

Answer 7

increased myeloid production (bacterial infection, CML)

Question 8

neutrophil granules contain

Answer 8

alkaline phosphatase, collagenase, lysozyme, lactoferrin

Question 9

activates macrophages

Answer 9

g-interferon

Question 10

cell surface marker for macrophages

Answer 10

CD-14

Question 11

bilobate nucleus with lots of granules

Answer 11

eosinphils

Question 12

so many granules you can’t see the nucleus

Answer 12

basophils

Question 13

basophil granules contain

Answer 13

heparin, histamine, leukotriene

Question 14

eosinphil granules contain

Answer 14

histamine, arylsulfatase

Question 15

how mast cells cause allergic reaction

Answer 15

binds Fc portion of IgE to membrane. IgE cross-links upon antigen binding, causing degranulation - releasing histamine

Question 16

prevents mast cell degranulation

Answer 16

cromolyn

Question 17

dendritic cells express

Answer 17

MHC-II and c receptor

Question 18

what B cells do when encountering an antigen

Answer 18

differentiate into plasma cells that produce antibodies and memory cells

Question 19

cancer of plasma cells

Answer 19

multiple myeloma

Question 20

off center nucleus, clock-face chromatin distribution, abundant RER and golgi

Answer 20

plasma cell

Question 21

universal recipient of RBCs

Answer 21

AB

Question 22

universal donor of plasma

Answer 22

AB

Question 23

universal donor of RBCs

Answer 23

O

Question 24

universal recpient of plasma

Answer 24

O

Question 25

tx for mom who gives birth to the oposite Rh- baby (first birth)

Answer 25

give Rho(D) immune globulin to mom to prevent immune sensititation to subsequent babies

Question 26

begins extrinsic coag path

Answer 26

factor VII

Question 27

activates factor VII

Answer 27

thromoplastin

Question 28

VIIa activates

Answer 28

X (joins intrinsic coag pathway)

Question 29

begins intrinsic coag pathway

Answer 29

XII activated to XIIa by collagen, BM and activated platelets

Question 30

hemophilia A a lack of

Answer 30

factor VIII

Question 31

hemophila B a lack of

Answer 31

factor IX (christmas disease)

Question 32

effect of bradykinin

Answer 32

increase of vasodilation, permeability, and pain

Question 33

turns prothrombin into thrombin

Answer 33

Va

Question 34

cleaves fibrinogen into fibrin

Answer 34

IIa (thrombin)

Question 35

creates fibrin mesh out of fibrin monomers

Answer 35

XIIIa (and Ca++)

Question 36

turns plasminogen into plasmin

Answer 36

kallikrein (tPA)

Question 37

actvates bradykinin

Answer 37

kallikrein

Question 38

degrades fibrin mesh

Answer 38

plasmin

Question 39

Vit K needed to mature

Answer 39

II, VII, IX, X, C, S

Question 40

reduces Vit K for use

Answer 40

epoxide reductase

Question 41

MOA of warfarin

Answer 41

inhibits epoxide reductase

Question 42

carries/protects VIII

Answer 42

vWF

Question 43

cleaves and inactivates Va, VIIIa

Answer 43

activated protein C

Question 44

activates protein C

Answer 44

thrombomudulin from endothelial cells

Question 45

cofactor for activated protein C

Answer 45

protein S

Question 46

MOA of heparin

Answer 46

activates antithrombin

Question 47

factor V leiden mutation effect

Answer 47

produces a factor V resistant to inhibition by activated protein C

Question 48

path of platelet plug formation

Answer 48

1) injury - vWF binds to exposed collegen upon endothelial damage 2) adhesion - platlets bind vWF at site of injury --> release ADP (helps platelet adhere to endothelium) and Ca (for coag cascade) 3) activation - > ADP binding to receptor induces GpIIb/IIIa expression at platelet surface 4) fibrinogen binds GpIIb/IIIa receptors and binds links platelets

Question 49

MOA of asprin

Answer 49

inhibits cyclooxxygenase preventing TXA2 synth

Question 50

MOA of ticlopidine and clopidogrel

Answer 50

inhibit ADP indiced expression of GpIIb/IIIa

Question 51

MOA of abciximab

Answer 51

inhibits GpIIb/IIIa directly