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Flashcards in HEME ONC Drugs Deck (58)
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1

Mineral/Vitamin: Ferrous Sulfate

1) Use: Iron defiecnt anemia
2) Class/MOA:
3) Side effects/ADEs: Constipation
4) Fun Facts

2

Mineral/Vitamin: Iron dextran = Iron sucrose

1) Use: FE Deficency Anemia
2) Class/MOA:
3) Side effects/ADEs: anaphalazis
4) Fun Facts

3

Mineral/Vitamin: Folic Acid

1) Use: PND, traumatic cardiac hemolytic anemia, folate defiency (alcoholism)
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

4

Mineral/Vitamin: Vitamin B12

1) Use: Pernicious Anemia
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

5

Desferrioxamine (Deferoozamine or Desferal)

1) Use: Thalasemias, or other disease with regular blood transfusions - helps avoid iron overload (causes cirrhosis, CHF, DM)
2) Class/MOA: IRON CHELATOR (NOT ORAL!)
3) Side effects/ADEs:
4) Fun Facts

6

Deferasirox (EXJADE)

1) Use: Thalasemias, or other disease with regular blood transfusions - helps avoid iron overload (causes cirrhosis, CHF, DM)
2) Class/MOA: Iron Cheltors ORAL
3) Side effects/ADEs:
4) Fun Facts

7

Epoeitin

1) Use: anemia
2) Class/MOA: GROWTH FACTOR EPO = increases RBC
3) Side effects/ADEs:
4) Fun Facts

8

Filgrastim (G-CSF; Neupogen); Sargramostim (GM-CSF; Leukine); Peg-Filgrastim (Neulasta)

1) Use: GROWTH FACTOR any chemo that causes neutropenia; meylosuppressive therapy
2) Class/MOA: stimulates proliferation, matruation and efficacy of NEUTROPHILS via JAK/STAT tyrosine kinase pathway
3) Side effects/ADEs:
4) Fun Facts: same as G-CSF

9

IL-11 (Oprelvekin, Neumega) Rx: thrombocytopenia

1) Use: GROWTH FACTOR thrombocytopenia
2) Class/MOA: stimulates the growth of primative MEGAKARYOCYTE progenitors - increase megakaryocytes, increase peripheral platelets
3) Side effects/ADEs: fatigue, headache, CVE
4) Fun Facts:

10

Growth Factor: Romiplostim (Nplade) - Thrombopoeitin analog - Rx for chronic ITP

1) Use: GROWTH FACTOR thrombocytopenia
2) Class/MOA: same as IL-12: stimulates growth of primative megakarycytic progenitors, increasing megakaryocytes, increasing platelets
3) Side effects/ADEs: fatigue, headache, CVE
4) Fun Facts

11

Asprinin

1) Use: PLATELET INHIBITOR
2) Class/MOA: Actylates and irreversibly inhibits COX-1 and COX-2 to prevent conversion of arachadonic acid to thromboxane A2
3) Side effects/ADEs: increase BT, no effect on PT, PTT | Gastric ulcertation, bleeding, hyperventilation, Reye's Syndr

12

Ticlopidine, Clopidogrel (Plavix)

1) Use: PLATELET INHIBITOR
2) Class/MOA: Inhibit platelet aggregation by irreversibly blocking ADP RECEPTORS | inhibit fibrinogen binding by preventing glycoprotein Iib/I

13

Abciximab (Rheopro), Eptidibatide (Integrilin) and Tirofibiban (Aggrastat)

1) Use: PLATELET INHIBITOR
2) Class/MOA: Monoclonal antibody that binds to the GLYCOPROTEIN RECEPTOR Ib/IIIa on activated platelets, preventing aggregation
3) Side effects/ADEs: bleeding, thrombocytop

14

Dipyridamole

1) Use: PLATELET INHIBITOR
2) Class/MOA: increase cAMP = decrease ADENOSINE uptake/cyclic nucleotide PDE = decreased aggregation
3) Side effects/ADEs: serious bleeding risk
4) Fun Facts

15

Heparin

1) Use: immediate ANTICOAG for PE, stroke, ACS, MI, DVT | used during pregnancy | follow PTT
2) Class/MOA: INHIBITS THROMBIN ACTION | cofactor for activation of ANTI-THROMBIN, decrease thrombin and Xa, short 1/2 life
3) Side effects/ADEs: Bleeding, thrombocytopenai (HIT),

16

Enoxaparin (LMWH, Lovenox)

1) Use: Anticoagulation
2) Class/MOA: Cofactor for activation of ANTITHROMBIN and Xa (work better on Xa), better bioavailibilty and 2-4 times longer 1/2 life - can be administered subQ and without lab monitoring
3) Side effects/ADEs: can't reverse esily

17

Lepirudin, Bilirudin

1) Use:
2) Class/MOA: Hirudin derivatives; directly INHIBITS THROMBIN
3) Side effects/ADEs:
4) Fun Facts: used as an alternative to heparin for anticoagulating patients with HIT

18

Argatroban

1) Use: HIT, patient with kidney dysfunction
2) Class/MOA: directly INHIBITS THROMBIN
3) Side effects/ADEs: falsely elevates INR levels
4) Fun Facts: irreversible

19

Warfarin

1) Use: Chronic anticoagulation | not used in pregnat women | follow PT/INR values
2) Class/MOA: interfears with normal synthesis of K depedent clotting factors through blocking | INHIBIT THROMBIN GENERATION
3) Side effects/ADEs: bleeding, teratogenic,

20

Alteplase (tPA)

1) Use: CVA, acute MI, PE
2) Class/MOA: converts plasminogen to plasmin and helps cleave fibrin mesh TPA
3) Side effects/ADEs: bleeding
4) Fun Facts

21

Protamine Sulfate

1) Use: REVERSES HEPRIN
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

22

DDAVP (Desmopressin)

1) Use: vWF disease
2) Class/MOA: RELEASES vWF stored in endothelium
3) Side effects/ADEs:
4) Fun Facts

23

Vitamin K

1) Use: REVERSES Warfarin
2) Class/MOA:
3) Side effects/ADEs:
4) Fun Facts

24

Novo VII

1) Use: potent means to stop bleeding!
2) Class/MOA: BASICALLY FACTOR VII | binds activated platelets and catalysex X-> Xa, which turns activated factor II -> Iia (thrombin)
3) Side effects/ADEs: thrombosis
4) Fun Facts

25

Aminocaproid Acid (AMICAR)

TREATMENT OF BLEEDING all anti fibrinolytic - a drug to stop a clot from breaking down

26

Cyclophoasphamide, Ifosphasmide

1) Use: NHL, breast/ovarian carcinomas | immunosupressant
2) Class/MOA: ANTINEOPLASTIC AGENT | ALKYLATING AGENT | Covalently links X-link (intrastrand) DNA at guanine N-7 | requires bioactivation by the liver
3) Side effects/ADEs: Myelosupression, hemor

27

Busulfan

1) Use: CML - ablate bone marrow before BM transplant
2) Class/MOA: ANTINEOPLASTIC AGENT | ALYKATING AGENT | lkylates DNA
3) Side effects/ADEs: Pulmonary fibrosis, hyperpigmentation
4) Fun Facts

28

Bendamustine

1) Use: Refractory CLL, low NHL
2) Class/MOA: ANTINEOPLASTIC AGENT | Alkylating agent - Nitrogen Mustard
3) Side effects/ADEs: NO allopecia, liver irritation, fatigue, rash
4) Fun Facts

29

Nitrosoureas (BCNU - Carmustine) & (CCNU - Lomustine)

1) Use: Brain tumors (including glioblastoma multifome)
2) Class/MOA: ANTINEOPLASTIC AGENT | ALKYLATING AGENT | Require bioactivation | cross BBB = CNS
3) Side effects/ADEs: CNS tocicity (dizziness, ataxia)
4) Fun Facts

30

Cisplatin (& mesna), Carboplatin

1) Use: Testicular, bladder, ovary and lung carcinomas
2) Class/MOA: ANTINEOPLASTIC AGENT | ALKYLATING AGENT | Cross-link DNA
3) Side effects/ADEs: Nephrotoxicity and acoustic nerve damage
4) Fun Facts