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Flashcards in Autonomic Rx Deck (55)
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1

Bethanchol

1) Activates Bowel and Bladder smooth m. Post-op and neurogenic ileus and urinary retention.
2) Direct Cholinomimetic.
4) Resistant to AchE.

2

Carbachol

1) Glaucoma, pupillary contraction, and relief of intraocular pressure.
2) Direct Cholinomimetic.
4) Carbon copy of Ach

3

Pilocarpine

1) Potent stim of sweat, tears, saliva. Contracts ciliary m of eye (open angle) and pupillary sphincter (narrow angle)
2) Direct Cholinomimetic
4) Resistant to AchE

4

Methacholine

1) Challenge test --> dx of asthma.
2) Direct Cholinomimetic, stim muscarinic r in airway

5

Neostigmine

1) Post-op and neurogenic ileus and urinary retention, myasthenia gravis, reversal of neuromuscular jxn blockade (post-op).
2) Indirect Cholinomimetic; increases Ach.
4) No CNS penetration

6

Pyridostigmine

1) Myasthenia gravis (long acting)
2) Indirect Cholinomimetic; increases Ach, increases strength.
4) No CNS penetration

7

Edrophonium

1) Diagnosis of myasthenia gravis (short acting).
2) Indirect Cholinomimetic; increases endogenous Ach

8

Physostigmine

1) Anticholinergic toxicity
2) Indirect Cholinomimetic; increases Ach.
4) crosses BBB

9

Donepezil

1) Alzheimers
2) Indirect Cholinomimetic; increases Ach

10

ADE of all Cholinomimetics

Exacerbation of COPD, asthma, and peptic ulcers

11

Organophosphate poisoning (e.g. Parathion)

Irreversibly inhib AchE. (DUMBBELSS) Diarrhea, Urination, Miosis, Bronchospasm, Bradycardia, Excitation of skeletal m and CNS, Lacrimation, Sweating, and Salivation

12

Rx for Organophosphate poisoning

Atropine + Pralidoxime = regenerate active AchE

13

Atropine Use/MOA

1) Blocks Organophosphate poisoning. Used to treat bradycardia and opthalmic applications
2) Muscarinic antagonist.

14

Atropine ADE

3) Increase body temp, rapid pulse, dry mouth, dry/flushed skin, cycloplegia, constipation. Can cause acute angle-glaucoma in elderly, urinary retention in men with BPH, hyperthermia in infants

15

Homatropine

1) Produce mydriasis and cycloplegia
2) Muscarinic antagonist

16

Tropicamide

1) Produce mydriasis and cycloplegia
2) Muscarinic antagonist

17

Benztropine

1) Rx for Parkinsons.
2) Muscarinic Antagonist

18

Scopolamine

1) Motion sickness.
2) Muscarinic antagonist

19

Tiotropium

1) Rx for COPD, Asthma.
2) Muscarinic antagonist

20

Ipratropium

1) Rx for COPD, Asthma.
2) Muscarinic antagonist

21

Oxybutynin

1) Reduce urgency in mild cystitis and reduce bladder spasms.
2) Muscarinic Antagonist

22

Glycopyrrolate

1) Parenteral: preop --> reduce airway secretions. PO: Rx for drooling, peptic ulcer
2) Muscarinic Antagonist

23

Epinephrine

1) Anaphylaxis, glaucoma (open angle), asthma, hypotension
2) Sympathomimetics; A1, A2, B1, B2. LOW dose selective for B1

24

NE

1) Hypotension (but low renal perfusion)
2) Sympathomimetics; A1, A2 > B1

25

Isoproterenol

1) Torsade de pointes (tachycardia decr low QT interval), bradyarrhythmias (but can worsen ischemia)
2) Sympathomimetics; B1=B2

26

Dopamine

1) Shock (renal perfusion), heart failure
2) Sympathomimetic; D1 (low dose) >B (medium dose) >A (high dose), inotropic and chronotropic

27

Dobutamine

1) Heart failure, cardiac stress testing
2) Sympathomimetic; B1>B2, inotropic and chronotropic)

28

Phenylephrine

1) Hypotension (vasoconstrictor), ocular procedures (mydriatic), rhinitis (decongestant)
2) Sympathomimetic; A1>A2

29

Albuterol

1) Acute asthma
2) Sympathomimetic; Selective B2-agonist (B2>B1)

30

Salmeterol

1) Long-term treatment of asthma or COPD control
2) Sympathomimetic; Selective B2-agonist (B2>B1)