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Flashcards in Psychiatry Deck (34)
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1

Trifluoperazine

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

2

Fluphenazine

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

3

Haloperidol

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: High potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: Mostly EPS (dyskinesia) b/c high potency
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

4

Chlorpromazine

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

5

Thioridazine

1) Use: Positive symptoms of schizophrenia, psychosis, mania, tourrettes
2) Class/MOA: Low potency, typical, antipsychotic. Block D2 receptor
3) Side effects/ADEs: blocking muscarinics (dry mouth), from blocking alpha 1 (hypotension), from blocking histamine (sedation), Neuroloeptic malignant syndromey
4) Fun Facts: Neurolepic malignant syndrome is dangerous toxicity of all antipsychotic

6

Olanzapine

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Olanzapine specific: weight gain
4) Fun Facts:

7

Clozapine

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Clozapine specific: weight gain, agranulocytosis and seizures.
4) Fun Facts: Must monitor WBC. Must watch clozapine clozely

8

Ziprasidone

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals. Ziprasidone prolongs QT interval.

9

Quetiapine

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

10

Risperadone

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

11

Aripiprazole

1) Use: Pos and negative schizoprenia symptoms. Bipolar, OCD, anxiety disorder, depression, mania, tourette's
2) Class/MOA: Atypical antipsychotic. Varied effect on 5-HT2, dopamine, alpha and H1 receptors
3) Side effects/ADEs: Fewer EPS and anticholinergics than typicals.

12

Lithium

1) Use: Bipolar, SIADH
2) Class/MOA: Not established. Related to phosphoinositol cascade (?)
3) Side effects/ADEs: Movement, Nephrogenic DI, hypOthyroidism, Pregnancy (LMNOP)
4) Fun Facts: May cause fetal cardiac defects, excreted by kidneys

13

Buspirone

1) Use: Generalized anziety disorder
2) Class/MOA: Stimulates 5-HT1A receptor.
3) Side effects/ADEs: No sedation, addiction or tolerance
4) Fun Facts: No interactions with barbituates or benzodiazepines

14

Fluoxetine

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

15

Paroxetine

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

16

Sertraline

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

17

Citalopram

1) Use: Depression, GAD, panic disorder, OCD, bulimia, PTSD, social phobias
2) Class/MOA: SSRI
3) Side effects/ADEs: GI stress, sexual dysfunction, serotonin syndrome (when combined with MAO inhibitors or TCAs)
4) Fun Facts: Takes 4-8 weeks to have an effect

18

Venlafaxine

1) Use: Depression. Venlafaxine also in GAD, panic disorders.
2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake
3) Side effects/ADEs:Increased BP

19

Duloxetine

1) Use: Depression, diabetic peripheral neuropathy.
2) Class/MOA: SNRI, Inhibit serotonin and NE reuptake (greater effect on NE than other SNRI-venlafaxine). Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
3) Side effects/ADEs:Increased BP

20

Amitriptyline

1) Use: Major depression, fibromyalgia
2) Class/MOA: 3rd generation tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Third generation TCAs have more anticholinergic side effects

21

Nortriptyline

1) Use: Major depression, fibromyalgia
2) Class/MOA: 2nd generation tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Second generation TCAs have fewer anticholinergic side effects

22

Imipramine

1) Use: Major depression, fibromyalgia, bedwetting
2) Class/MOA: Tricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: use for bedwetting is imipramine specific.

23

Desipramine

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)
4) Fun Facts: Less sedating, higher seizure threshold. .

24

Clomipramine

1) Use: Major depression, fibromyalgia. First line OCD.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)

25

Doxepin

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)

26

Amoxapine

1) Use: Major depression, fibromyalgia.
2) Class/MOA: Ttricyclic antidepression. Block NE and serotonin
3) Side effects/ADEs: Alpha blocking side effects (postural hypotension), anticholinergic effects (tachycardia, urinary retention, dry mouth), Sedation. Toxicity: Convulsions, coma, cardiotoxicity (treat with NaBicarb)

27

Tranylcypromine

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John's wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

28

Phenelzine

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John's wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

29

Isocarboxazid

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John's wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)

30

Selegiline

1) Use: Atypical depression, anxiety, hypochondriasis
2) Class/MOA: Nonselective MAO inhibitor. Increases levels of Ne, serotonin and dopamine (all amine NTs)
3) Side effects/ADEs: Hypertensive crisis, CNS stimulation. Serotonin syndrome (with SSRI, TCA, St. John's wort, meperidine, dextromethorphan)
4) Fun Facts: MAO Takes Pride In Shanghai (tranylcypromine, phenelzine, isocarboxazid, selegilint)