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Med School: Semester 2 > Heme2a > Flashcards

Flashcards in Heme2a Deck (30):
1

What is the translocation for Burkitt lymphoma?

t(8;14) c-myc

2

What is the translocation for Follicular Lymphoma?

t(14;18) bcl-2

3

What is the translocation for AML M3 type?

t(15;17) APL:RARA

4

What is the translocation for Ewing sarcoma?

t(11;22)

5

What is the translocation for Mantle Cell Lymphoma?

t(11;14)

6

What is the translocation for CML?

t(9:22) Ph chromosome

7

What are the 3 major conditions associated with multiple myeloma?

a. Plasma cells activate RANK receptors on osteoclasts will break down bone.

b. Monoclonal Ig is made- M spike but low diversity

c. Lights chains are also released- proteinuria and high serum protein

8

What is MGUS?

High serum protein (M spike), but not other symptoms of MM.

9

What is the difference in Ig_ between MM and Waldenstrom?

MM: IgG and sometimes IgA

Waldenstrom: IgM

10

On what test is the M spike detected?

SPEP

11

What are the three under the umbrella of myeloproliferative disorder?

a. Polycythemia vera
b. CML
c. Essential Thrombocythemia

12

What two conditions can have hyperviscosity?

a. Polycythemia Vera (low EPO is a hallmark)

b. Waldenstroms: high IgM

13

What three conditions have a JAK2 mutation?

a. Polycythemia Vera
b. Myelofibrosis
c. Essential Thrombocythemia

14

CML
a. What cells are especially elevated?
b. What is the mutation?
c. What receptor is involved?
d. How do you treat it?
e. How can you distinguish CML from infection?

a. basophils
b. (9;22) BCR;ABL
c. tyrosine kinase
d. imatinib
e. granulocytes are LAP(-)

15

Can CML become AML or ALL?

Both. 2/3 become AML. 1/3 become ALL.

The mutation is in the CD34+ HSC.

16

How do you treat Follicular Lymphoma?

Rituximab (anti CD20)

17

What virus can cause Marginal Zone Lymphoma?

H. pylori

18

Reed-Sternberg cells are CD_?

CD 15+ and CD30+

19

What are the 4 types of Hodgkins Lymphoma?

a. Nodular Sclerosing (70%)
b. Lymphocyte Rich (best prognosis)
c. Lymphocyte Depleted (worst prognosis)
d. Mixed Cellularity (lots of eosinophils)

20

What is the normal range for WBCs?

5K to 10K

21

Hodgkins is associated with an increase in IL-_?

IL-5

22

What is the definition of acute leukemia?

>20% blasts in marrow

23

What diseases are tDt+?

ALL

24

What are two characteristics of Acute Monocytic Leukemia?

a. Goes to the gums

b. no MPO

25

What requires prophylaxis for your brain and balls?

B-ALL

26

What disease has smudge cells? What is a major symptom? And these B cells are CD? and CD?

CLL
Hypogammaglobulinemia
CD5+ and CD20+

27

Adult T Cell Leukemia Lymphoma has CD_ T cells, and what symptom distinguishes it from MM?

CD4+ T Cells.

Rash distinguishes it from MM.

28

What are the 3 requirements for MM?

a. monoclonal plasma cells in marrow >= 10%
b. monoclonal protein present in serum or urine
c. CRAB (myeloma related organ dysfunction)

29

What is the most common chromosome abnormality in MM?

14q32

30

Low albumin levels in MM are associated with what?

IL-6