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Med School: Semester 2 > Heme2b > Flashcards

Flashcards in Heme2b Deck (22):
1

What is APL?

Acute Promyelocytic Leukemia. Translocation of retinoic acid receptor-alpha from chromosome 17 to chromosome 15.

2

How can we treat APL?

ATRA (all trans-retinoic acid).

3

What are Auer rods? When are they found?

Auer Rods are found in AML. They are peroxidase-positive cytoplasmic inclusions.

4

Why must you Dx APL quickly?

DIC

5

What FAB designation does APL have?

M3

6

How do we treat APL?

ATRA + ATO. Maintenance with pulse ATRA.

Relapse = ATO

7

How do we treat CBF AML?

Ind: Cytarabine

Con: High Dose Cytarabine

Relapse: Alll-BMT

8

Tell me about the patient, genetics and comments for Burkitt Lymphoma.

P: young adults, adolescents
G: t(8;14), c-myc (8) and heavy chain Ig (14)
C: EBV assoc., jaw lesions, endemic in Africa

9

Tell me about the patient, genetics and comments for Diffuse Large B-Cell Lymphoma.

P: older adults, 20% children
G: t(11;14)
C: most common type of non-Hodgkin lymphoma in adults.

10

Tell me about the patient, genetics and comments for Mantle Cell Lymphoma.

P: older males
G: t(11;14), cylcin-D1 (11), heavy chain Ig (14)
C: CD5+

11

Tell me about the patient, genetics and comments for Follicular Lymphoma.

P: adults
G: t(14;18), heavy chain (14), bcl-2 (18)
C: indolent course; blc-2 inhibits apoptosis, "waxing/waning" lymphadenopathy.

12

Hodgkins vs. Non-Hodgkins: localized nodes.

Hodgkins

13

Hodgkins vs. Non-Hodgkins: Reed Sternberg Cells.

Hodgkins

14

Hodgkins vs. Non-Hodgkins: 50% association with EBV.

Hodgkins

15

Hodgkins vs. Non-Hodgkins: HIV association.

Non-Hodgkins

16

Hodgkins vs. Non-Hodgkins: "B" signs.

Hodgkins (fever, night sweats, weight loss)

17

Hodgkins vs. Non-Hodgkins: majority B-Cells.

Non-Hodgkins

18

Hodgkins vs. Non-Hodgkins: 20-40y/o

Non-Hodgkins

19

Hodgkins vs. Non-Hodgkins: bi-modal, youg and >50y/o

Hodgkins

20

What is the pneumonic "CRAB" and what does it refer to?

Calcium is up
Renal failure
Anemia
Bone lesion

This refers to Multiple Myeloma.

21

What disease has to do with a monoclonal M protein spike?

Multiple Myeloma.

22

What are the M spike and plasma cell values for MGUS, smoldering multiple myeloma and multiple myeloma?

MGUS*: = 3g M spike OR >= 10% PC
MM: M spike +, >= 10% PC, and CRAB(+)

*CRAB(-)