Flashcards in Heme2b Deck (22):
What is APL?
Acute Promyelocytic Leukemia. Translocation of retinoic acid receptor-alpha from chromosome 17 to chromosome 15.
How can we treat APL?
ATRA (all trans-retinoic acid).
What are Auer rods? When are they found?
Auer Rods are found in AML. They are peroxidase-positive cytoplasmic inclusions.
Why must you Dx APL quickly?
What FAB designation does APL have?
How do we treat APL?
ATRA + ATO. Maintenance with pulse ATRA.
Relapse = ATO
How do we treat CBF AML?
Con: High Dose Cytarabine
Tell me about the patient, genetics and comments for Burkitt Lymphoma.
P: young adults, adolescents
G: t(8;14), c-myc (8) and heavy chain Ig (14)
C: EBV assoc., jaw lesions, endemic in Africa
Tell me about the patient, genetics and comments for Diffuse Large B-Cell Lymphoma.
P: older adults, 20% children
C: most common type of non-Hodgkin lymphoma in adults.
Tell me about the patient, genetics and comments for Mantle Cell Lymphoma.
P: older males
G: t(11;14), cylcin-D1 (11), heavy chain Ig (14)
Tell me about the patient, genetics and comments for Follicular Lymphoma.
G: t(14;18), heavy chain (14), bcl-2 (18)
C: indolent course; blc-2 inhibits apoptosis, "waxing/waning" lymphadenopathy.
Hodgkins vs. Non-Hodgkins: localized nodes.
Hodgkins vs. Non-Hodgkins: Reed Sternberg Cells.
Hodgkins vs. Non-Hodgkins: 50% association with EBV.
Hodgkins vs. Non-Hodgkins: HIV association.
Hodgkins vs. Non-Hodgkins: "B" signs.
Hodgkins (fever, night sweats, weight loss)
Hodgkins vs. Non-Hodgkins: majority B-Cells.
Hodgkins vs. Non-Hodgkins: 20-40y/o
Hodgkins vs. Non-Hodgkins: bi-modal, youg and >50y/o
What is the pneumonic "CRAB" and what does it refer to?
Calcium is up
This refers to Multiple Myeloma.
What disease has to do with a monoclonal M protein spike?