Flashcards in Hemeonc MSK Deck (110)
thrombocytopenia/platelet dysfunction results in
Cell surface marker for Macrophages?
What causes eosinophilia?
Acute interstitial neph
Collagen vascular dx
- Churgg Strauss
funtion of a mast cell?
binds to the Fc portion of IgE to membrane
- cross linking of IgE causes degranulation releasing histamine, heparin and eosinophil chemotactic factors
only APC that can activate NK cells?
Dendritic cells- acts as a linke between innate and adaptive immune system
marker of T cells, necessary for t cell activation
what enzyme does warfarin inhibit?
epoxide reductase which usually activates vitamin K to make mature clotting factors
Role of kallikrein?
activates bradykinin and complement cascade (via activation of plasmin)
C1 esterase inhibitor?
inhibits kallikrein > brakykinin, so a deficiency causes a buildup of bradykinin, leading to angioedema
role of plasmin?
decreases the fibrin clot
What does the endothelial cell make in terms of thrombogenesis?
when do you see a acanthocyte?
When do you see target cells?
diagnostic confirmation fo B Thal minor
what are the genetics behind beta thal?
- point mutations in splice sites and promoter sequences decreasing B globin synthesis
(Alpha thal = gene deletions)
crew cut on skull xray, chipmunk facies
beta thal major- homozygotes, stop codon, increased HbF
what are the aggregates seen in basophilic stipling?
where in the bone does lead target?
epiphysis of distal femur and proximal tibia
Pathogenesis of sideroblastic anemia
X linked defect in d-ALA synthase gene
- also seen in alcohol, lead and INH deficiency
tx of sideroblastic anemia?
pyridoxine- B6 is a cofactor for ALA synthase
findings of intravascular hemolysis
Extravascular hemolysis findings
increased UCB > jaundice
What viruses can cause Aplastic anemia?
how does pyruvate kinase deficiency cause anemia?
defective pyruvate kinase causes decreased ATP > rigid RBCs
- hemolytic anemia in newborn
whats the defect behidn HbC?
glutamic acid to lysine mutation in B globin gene
treatment of PNH?
genetics of HbS?
substitution of glutamic acid with val in Beta chain