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Flashcards in Oncogenes Deck (19)
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1
Q

What are the growth factor receptors?

A
  1. ERB-2 (her2/neu)
  2. Ret
  3. Kit
2
Q

What are the signal transducers?

A
  1. Ras

2. ABL

3
Q

What are the nuclear regulators?

A
  1. C-myc
  2. N-myc
  3. L-myc
4
Q

What are the cell cycle regulators?

A
  1. Cyclin D1

2. CDK4

5
Q

What are the tumor suppressor genes?

A
  1. p53

2. Rb

6
Q

What is the regulator of apoptosis?

A

Bcl2

7
Q

What is the f=growth factor?

A

PDGF

8
Q

PDGF

A
  • overexpression seen in astrocytoma
9
Q

ERB2

A
  • HER2/neu

- amplification of epidermal growth factor seen in breast cancer

10
Q

Ret

A
  • growth factor

- point mutation seen in MEN 2A, 2B and sporadic medullary carcinoma of the thyroid

11
Q

Kit

A
  • stem cell growth factor point mutation seen in GIST
12
Q

Ras

A
  • GTP binding point mutation- GAP usually turns off Ras but this is mutated to turn it on
  • seen in carcinomas, melanomas and lymphomas
13
Q

ABL

A
  • tyrosine kinase translocation t9;22 with BCR

- CML and some ALL

14
Q

C-myc

A
  • transcription factor regulator, t(8;14)

- Burkitt lymphoma

15
Q

Chromosome 14 has what?

A

the Ig heavy chain = always expressed

16
Q

N-myc

A

amplification of transcription factor

- seen in neuroblastoma

17
Q

L-myc

A
  • amplification of transcription factor

- seen in small cell lung carcinoma

18
Q

Cyclin D1

A
  • cell cycle regulator, translocation t11;14
  • cyclin D allows G1 -> S
  • Mantle cell lymphoma
19
Q

CDK4

A

amplification of cell cycle regulator

- seen in melanoma