Flashcards in Signaling pathways Deck (66)
FSH, LH, ACTH, TSH
CRH, hCG, ADH (V2 receptor), MSH, PTH
ADH (V1 receptor)
Instrinsic tyrosine kinase
What pathway do instrinsic tyrosine kinases utilize?
MAP kinase pathway
Receptor assoc tyrosine kinases
Immunomodulators: cytokines IL-2, IL-6, IL-8, IFN
What pathway do receptor assoc tyrposine kinases utilize?
How does T3 increase CO?
binds to B1 receptors on the heart
how does T3/T4 increase BMR?
increase Na/K ATPase
What do you see elevated in the urine of a child w adrenal neuroblastoma?
HVA: homovanilic acid, a breakdown product of DA
what is the genetic mutation is neuroblastoma and what is the tumor marker>
overexpression of N-myc oncogene > rapid tumor progression
- tumor marker = Bombesin
- neurofilament stain
people with Hashimotos thyroiditis have an increased risk of what cancer?
very tender thyroid, increased ESR
subacute thyroiditis: self limited hypothyroidism often following a flu like illness
- see granulomatous inflammation on histo
fixed, rock hard and painless goider
Reidels thyroiditis: thyroid replaced by fibrous tissue
Jod-Basedow phenomenon- what is it? what can cause it?
when someone with iodine deficiecny is given iodine> hyyperthyroidism!
- seen when given contrast radio-iodine or amiodarone
what is the cause of death in thyroid storm?
death by arrhythmia
thyroid cancer w empty appearing nuclei, psammoma bodies, whats the cancer and assoc gene?
- Papillary carcnoma
- Ret gene mutation
thyroid cancer that produces calcitonin, sheets of cells in amyloid stroma, what is it and what is gene and associations?
- Medullary carcinoma
- ret gene mutation, assoc with MEN 2A and 2B
When do you see psammoma bodies? 4 instances
Papillary carcinoma of thyroid
Serous cystadenocarcinoma of the ovary
hypocalcemia, shortened 4th/5th digits, short stature
Pseudohypoparathyrodism: Albright's hereditary osteodystrophy
- AD kidney unresponsive to PTH
how do you diagnose Acromegaly?
- increase serum IGF-1
- failure to suppress serum GH following oral glucose tolerance test
what inhibits the release of GH?
glucose and somatostatin
What are the treatments for Nephrogenic diabetes insipidus?
What drugs can casue secondary nephrogenic DI?
What drug can cause SIADH?
Treatment of SIADH?
how do you treat carcinoid syndrome?
somatostatin analog = Octreotide
what is the inheritance of MEN syndromes?