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Flashcards in HemOnc Deck (36):
1

kallikrein

needs 12a
makes plasmin/bradykinin

2

hemophilia test

PTT

3

direct thrombin inhibitors

lepirudin
bivalirudin
desirudin
argatroban
dabagatron

4

factor Xa inhibitors

rivaroxaban
apixaban

5

warfarin vs. heparin

warfarin is longer, slower, increases PT

6

HIT

Ab to platelet factor 4
treat with direct thrombin inhibitor early until warfarin builds up

7

teardrop RBC

myelofibrosis

8

degma cell

bite cell

9

target cell

THAL
thalessemia
hemophilia C
aplenia
liver disease (also spurs)

10

spur cells

liver disease
abetalipoproteinemia

11

burr cell

uremia

12

wine urine, pain, neuro

acute intermittent porphyria
-UP1 synthase/porphyrobil. deaminase

get from metaclopromide, rifampin, seizure Tx

treat with glucose, heme

13

porphyria cutanea tarda

uroporphyrinogen decarboxylase

tea urine, hairy, blisters
Hep C, alcohol, and LFT

14

high protoporphyrin

lead poisoning

15

3/4 alpha thalassemia

HbH = B4

16

high Fe and ferritin

sideroblastic anemia
give B6

or hemochromatosis

17

orotic aciduria

UMP synthase deficiency
macrocytic anemia
normal ammonia

18

macrocytic normoblastic

5FU
ziduvudine
hydroxyurea

19

paroxysmal nocturnal hematuria

missing CD55/59
complement attack
positive acid lysis Ham's test

20

warm agglutinins

IgG
lupus
EBV, CLL (also cold)

21

pyruvate DH deficiency

neurological

22

Direct Coombs

antihuman Ab added to patient RBC
positive in HD of newborn, drug induced hemolysis, transfusion reactions

23

Indirect Coombs

patient serum added to normal RBC
screen transfusion, maternal Ab to fetus screen

24

normal PT/PTT

aspirin

25

high PTT, high bleeding time

von Willebrand disease - fail to stabilize 8
treat with DDAVP

26

deficient ADAMS 13

= TTP
vWF active multimers
schistocytes, LDH,
hemolysis, renal insuff, thrombocytopenia (HUS)
+ neuro, fever

27

Pelger-Heut bodies

myelodysplastic syndrome
"pince-nez"

28

myeloproliferative disorder gene

JAK2
get myelofibrosis

29

get leukomoid

TOF
Down
Kawasaki

30

multiple myeloma gets

high Ca --> rouloux
renal insufficiency - SPEP/UPEP
anemia, back pain

31

Mallory bodies

alcoholic liver
eosinophilic cytoplasmic globules in liver

32

CD13/33

AML

33

15;17

AML M3
auer rods

34

8;21

AML
Downs

35

risk for AML

Fanconi
Bloom
alkylating agent chemo, radiation
benzene
myeloproliferative
myelodysplastic

36

CLL

70 yo
B cell markers
autoimmune hemolytic anemia