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Flashcards in hemonc Deck (20)
1

leukemia

cancer of marrow + lymph systems
LEUKOCYTE EXPLOSION!

myeloid vs lymphoid, acute or chronic

cure: bone marrow tx

2

leukemia types x2

acute or chronic
myeloid or lymphoid

3

acute myeloid leukemia

cancer of WBC - all immature
inhibits healthy WBC, RBC, and plt

BLASTS! BLASTS! BLASTS!

4

AML poor prognosis

- 50+
- secondary AML (s/t chemo tx)
- genetic mutation

5

AML s/s

fever
fatigue
pallor
ecchymosis
bone pain
infection
SOB

auer rods, pancytopenia, splenomegaly, hepatomegaly, renal failure

6

acute lymphoid leukemia

rapid T & B in marrow
adults = BCR-ABL + philadelphia genes
tx: in-depth in/out hospital

7

chronic myeloid leukemia
- hallmark
- phases x3

slow growing, diagnosed at PCP office visits
- sx: chronic fatigue
- phases: chronic, accelerated, blast (dep on # blast in bone marrow)

8

lymphoma

cancer of B, T, NK cells
originating in the lymphatic system
- hodgkin vs non

9

hodgkin lymphoma sx/presentation

sx: fever, chill, night sweats, wt loss over mos
pres: large nodes, mediastinal mass

10

hodgkin lymphoma dx

PET (PDG+)
biopsy = Reed Sternberg cells !!!

11

Reed Sternberg cells

characteristic of hodgkin lymphoma

12

non-hodgkin lymphoma

everything else that isn't hodgkin
tx: CHOP-R

13

multiple myeloma

malignant PLASMA CELLS (B-cells - monoclonal immunoglobulin)

proliferation in bone marrow, if mass occurs outside marrow: plasmacytoma

14

multiple myeloma hallmark sx

bone disease - pain, fractures d/t hypercalcemia bone turnover

also, anemia (marrow is wack)

15

multiple myeloma dx

10+% monoclonal plasma cell in bone marrow
+/- bx: plasmacytoma
monoclona protein in serum or urine

16

multiple myeloma CRAB

organ dysfxn!
C a increased (10.5+)
R enal insufficiency (creat 2+)
A nemia (hgb under 10)
B one lesions (lytic)

17

multiple myeloma types x3

MGUS (likely won't progress)
smoldering (asx)
plasmacytoma

18

ALL sx

fever
anorexia
bone joint pain
dyspnea
pallor
purpura/petechiae
hepatosplenomegaly

19

CML sx

massive splenomegaly
malaise
fever
wt loss
bone/joint pain
leukocytosis

20

chronic lymphoid leukemia s/s

recurrent infection
malaise
anorexia
fatigue
splenomegaly
bleeding
lymphocytosis