Hepatitis Flashcards
Non infectious hepatitis
radiation
chemicals
AI disease
toxins
infectious hepatitis
viral
bacterial
parastici
Viral hepatitis
most common
HAV,HBV,HCV,HDV,HEV
Symptoms with acute disease
jaundice
dark urine
vomiting
abdom pain
Sympt w chronic hepatitis
prolonged..
prolonged elevation of serum
transamine levels >6mos
seen with HBV/HCV
Hep A
also called?
most?
nucleotide? (n)
contaminated…
excreted in
limiting?
liver failure?
infectious or short Hep
most common form
NON ENVELOPED RNA
contam food/water, excreted in bile/feces (viral ag in feces)
self limiting resolves in 3wks
liverfailure rare
Markers to diagnose Hep A
IgM anti-HAV (acute infection, detect prior to sympt)
IgG-Anti-HAV soon after IgM
life long immunity
IgM negative and IgG pos in HEP A means?
past infection
HEP B vaccine?
yes vaccine for kids/travelers
RT-PCR more sensitive
Hep B
also called?
phases?
most..
high incidence in?
transfusions
surfaces?
bf?
serum hepatitis/ long incubation
acute and chronic
most ubiquitous
high incidence 25-45yrs
HBV bld transfusions rare
Can live on surface for 7days
all bf
Hep B high risk behaviors and routes of infection
high risk - sexual behavior
drug needles
immigrants
3 routes:
parenteral - eating
parinatal - preg
sexual
Seromarkes for HEP B
what kind of virus
site of replication?
ag synth in?
DNA virus
liver prim state of replication
Ag synth in nuceli of hepatocytes - cytoplasm protein coat
HBcAg
testing
location
during what phase
core of virus
no test
only presnet in nuclei of hepatocyte
during acute infection
HBsAG
testing of
not infectious but can
chronic carriers
complete viral clearance
ONLY MARKER
can be pos?
hep B surface protein
testing all infect blood units
not infect but can indicate presence
chronic carriers potentially infect
complete viral clearance pt develops ab to HBsAG
ONLY MARKER DETECTED W NEW INFECTION
can be pos 10-20dys post vacc
HBeAg
additional ag ID’d
HBsAb
suggests past infection
future immunity
+ recov from acute/chronic
aquired immunity
= not recovered/inadeq immune response
Anti-HBc Total
differentiates?
when what things are negative?
diff between recent/chronic HBV
when HBsAg and Anti-HB markers are negative
Anti-HBc IgM
pts w …have low
exacerbation
specific for acute HBV
pts w chronic HBV may presist at low levels
exacerbation of chronic may also test positive
HBe Ag envelope Ag
in serum w
anti…..incidates
assoc w core of virus
in serum w acute/chronic
correlates w infectious particles
Anti-HBe indicates low infectivity
HBcAg + HBsAg indicates?
severe course
HBeAb
during recovery can be detectable
for years
low levels indicate low risk
Chronic infection w Hep B
how many recover ?
indicator of?
how many have had since childhood?
msot effective treatment?
90% recover within 6 mos
indicator of Anti-HBs
25% have had since childhood
vaccination most effective
4 phases of Hep B
immune tolerance
clearance
low/non replicating
reactivation
Active replicating Hep B
HBeAg (+) Anti-HBe (=)
