Histamine, Serotonin And Ergot Alkaloids Flashcards Preview

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Flashcards in Histamine, Serotonin And Ergot Alkaloids Deck (15)
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Precursor of histamine

Histidine
E: monoamine oxidase and diamine oxidase

1

Excess production of histamine detected by

Imidazole acetic acid in urine

2

Triple response

Wheal, flush, flare

3

Histamine:smooth muscle

H1
Ant: diphenhydramine

4

Histamine: stomach, heart, mast cell

H2
Ant: cemitidine

5

H1 blocker

Diphenhydramine, chlorpheniramine, cyclizine, promethazine

SE: drowsiness, dry mouth, ortho static hypotension

6

2nd gen H1 blocker

Ceterizine, loratidine

SE:fatal arrhythmia with azoles

7

Happy hormone

Serotonin

8

Serotonin: Vomiting/antagonist

5-HT3/ondansetron

9

Serotonin: Smooth muscles, platelets

5-HT2

10

Serotonin: brain

5HT1D

11

Serotonin: migraine
5HT1D agonist

Sumatriptan, zolmitriptan

12

____ produced by fungus in wet or spoiled grain/St. Anthony's fire
Partial agonist at a-adrenoreceptors and 5-HT receptors

Ergot alkaloids

13

Vasoselective Ergot alkaloid (5-HT2 receptor antagonist)

Ergotamine

DOC for Migraine, cluster headache

SE: uterine spasm, GI upset, vasospasm
Antidote: nitroprusside

14

Ergot Alkaloid: Uteroselective (5-HT2 receptor antagonist)

Ergonovine, methylergonovine

DOC: postpartum bleeding, migraine

Abortifacient