NSAIDS, Acetaminophen, DMARDS, anti-Gout Flashcards Preview

Pharmacology > NSAIDS, Acetaminophen, DMARDS, anti-Gout > Flashcards

Flashcards in NSAIDS, Acetaminophen, DMARDS, anti-Gout Deck (13)
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0

Non-selective NSAIDs

Ibuprofen, indomethacin, ketorolac, piroxicam

1

NSAID contraindicated in gout

Aspirin

2

Aspirin dosage (mg/d): usage

<300: inhibit platelet aggregation
300-2400: antipyretic and analgesic
2400-4000: anti-inflammatory

3

Only IV NSAID
restricted to 72hrs only

Ketorolac

4

DOC for closure of PDA

Indomethacin

5

Antidote for acetaminophen toxicity

N-acetylcysteine

6

Hyperbilirubinemia (PCM toxicity)

Stage II: 24-72hrs

7

Toxic dose/lethal dose

TD: 150mg/kg, 21 500 mg tab
LD: 15g, 30 500mg tab

8

DMARDS

for connective tissue dse
6wks-6months before effective

9

DMARDS

Methotrexate (leucovorin-rescue agent), DOC for RA:AICAR

Ifliximab: TNF-a
Azthioprine: 6-thioguanine, supress B-, T-cell
Chloroquine: supress T-lymph response
Cyclophosphamide: phosphoramide mustard
Cyclosporine: inhibits IL-1 and 2
Mycophenolate mofetil: inhibits IMP dehydrogenase
Sulfasalazine: inhibits cytokines



10

Colchicine

Microtubule assembly inhibitor, decreases macrophage migration and phagocytosis

11

Uricosuric agent

Probenecid, sulfinpyrazone
Inc uric acid excretion

12

Xanthine oxidase inhibitor

Allopurinol
For chronic gout