Coagulation Disorders Flashcards Preview

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Flashcards in Coagulation Disorders Deck (14)
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Intrinsic pathway (clotting factors)

PTT
V, VIII, IX, X, XI
XII, PT, fibrogen

1

Extrinsic pathway (clotting factor)

PT
V, VII, X, PT, fibrogen

2

Aspirin (MOA)

Inhibits platelet activation

3

Aspirin: toxic dose

Lethal dose

150mg/kg

500mg/kg

*uncoupler of oxidative phosphorylation

4

Samter triad of aspirin toxicity

Asthma
Aspirin sensitivity
Nasal polyps

5

DOC for prevention of retstenosis in PCI

Abciximab, Eptifibatide, Tirofiban

Antiplatelet: GPIIb/IIIa inhibitor

6

MOA Clopidogrel, ticlopidine, prasugel

ADP inhibitor

7

PDE III inhibitor

Dipyridamole, Cilostazol

Thromboembolic prophylaxis

8

Antiplatelet vs anticoagulant

Arterial vs. venous

9

Indirect thrombin inhibitors

Heparin, enoxaparin, LMWH

PTT (activates antithrombin III)

Antidote: Protamine

10

Direct thrombin inhibitors

Warfarin

PT (II, VII,IX, X)

Antidote: Vit K, FFP

11

Anticoagulant overlap

To bypass initial prothrombic effect of warfarin (antithrombin effect after 8-60 hrs after administration)

12

t-PA analog

Streptokinase, altaplase

Antidote: aminocalproic acid/tranexamic acid

13

DOC for hemophilia A and Von Willebrand dse

Desmopressin