Hodgkin Lymphomas Flashcards Preview

SBL Exam 1 WBCs, Spleen, and Thymus > Hodgkin Lymphomas > Flashcards

Flashcards in Hodgkin Lymphomas Deck (20)
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1

Differentiate NHL from HL.

NHL:

-frequently extranodal and diffuse

-masses mostly composed of neoplastic lymphocytes

 

HL:

- single nodal and contiguous mass

-masses mostly composed of inflammatory cells and fibrosis

-masses precipitated by Reed-Sternberg cells (special type of neoplastic B cell) which release chemokines

 

2

What are the classifications of HL?

-nodular sclerosis

-mixed cellularity

-lymphocyte-rich

-lymphocyte depleted

-lymphocyte predominance

3

What are Reed-Sternberg cells?

-neoplastic B cell causing HL

-large cell with multilobed nuclei with prominent nucleoli giving "owl-eye" appearance

4

What is the most common type of HL?

nodular sclerosis type (65-70%)

5

What is the least common type of HL?

lymphocyte depleted

6

What is the nodular sclerosis type of HL?

(infiltrate, markers)

-frequent lacunar RS cells

-fibrous bands forming nodules

-mixed cell infiltrate

-not associated with EBV

-"classic" RS cell markers (CD15, CD30)

7

What is the mixed cellularity type of HL?

(infiltrate, markers)

-mononuclear variant and RS cells

-mixed cell infiltrate

-strong EBV association

-"classic" RS cell markers (CD15, CD30)

-

8

What is the common presentation of nodular sclerosis HL?

-young adults (equal amongst M/F)

-painless cervical and medistinal lymphadenopathy

-early stages and asymptomatic

9

What is the prognosis of nodular sclerosis HL?

-excellent prognosis

10

What is the common presentation of mixed cellularity HL?

-greater in males

-biphasic; young adults and adults older than 55

-painless lymphadenopathy

-later stages with fever, night sweats and weight loss

11

What is the prognosis of mixed cellularity HL?

-very good prognosis

12

What is the lymphocyte rich type of HL?

(infiltrate, markers)

-mononuclear and RS cells

-primarily lymphocyte inflitrate

-partial association with EBV

-"classic" RS cell markers (CD15, CD30)

13

What is the common presentation of lymphocyte rich HL?

-older adults

-more frequent in men

-uncommon

14

What is the prognosis of lymphocyte rich HL?

-best prognosis

15

What is the lymphocyte depleted type of HL?

(infiltrate, markers)

-reticular variant RS cells

-frequent RS cells, scant lymphocytes

-EBV+

-"classic" RS cell markers (CD15, CD30)

16

What is the common presentation of lymphocyte depleted HL?

-older men -or- HIV infected any age

-painless lymphadenopathy

-later stages with fever, night sweats and weight loss

17

What is the prognosis of lymphocyte depleted HL?

-compartively worst prognosis but still good

18

What is the lymphocyte predominance type of HL?

(infiltrate, markers)

-abnormal L&H RS variant; multilobed nucleus "popcorn cell"

-DC and B cell infiltate (absent eosinophils and plasma cells)

-not associated with EBV

-atypical RS cell markers (BCL6 and CD20; no CD15 and CD30)

 

19

What is the common presentation of lymphocyte predominance HL?

-young males (*nodular was young but equal)

-painless cervical and medistinal lymphadenopathy

-early stages and asymptomatic

 

*otherwise very similar presentation to nodular

20

What is the prognosis of lymphocyte pedominance HL?

-excellent prognosis

-higher recurrance than others