What is leukopenia?
low WBC (~<5,000 cells/mm3)
What are the main causes of neutropenia?
-supression of stem cells or precursors (cancer, drugs)
-ineffective hematopoiesis (precursors die in bone marrow) (MDS)
-immune injury to cells
-increased peripheral use (severe infections)
What is agranulocytosis?
Decreased levels of neutrophils that there is a clinically significant change of infection.
What is the main cause of agranulocytosis?
What is leukophila?
high WBC (~>10,000 cells/mm3)
What are the main causes of leukocytosis?
Increased production in marrow:
-myeloproliferative disorders (MPD)
Increased release from marrow:
What are common causes of neutrophilia?
-acute bacterial infections
-sterile inflammation tissue necrosis (ie. MI and burns)
-high cortisol (releases marginated neutrophils)
What are common causes of eosinophilia?
What are common causes of basophilia?
RARE, think myeloproliferative disorders (MPD/CML)
What are common causes of monocytosis?
-chronic infections (granulomatous disease)
What are common causes of lymphocytosis?
-Bordetella pertussis (prevents lymphocyte entry into LN)