Leukopenia/Leukocytosis Flashcards Preview

SBL Exam 1 WBCs, Spleen, and Thymus > Leukopenia/Leukocytosis > Flashcards

Flashcards in Leukopenia/Leukocytosis Deck (11)
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1

What is leukopenia?

low WBC (~<5,000 cells/mm3)

2

What are the main causes of neutropenia?

Decreased production:

-supression of stem cells or precursors (cancer, drugs)

-ineffective hematopoiesis (precursors die in bone marrow) (MDS)

-impaired differentiation

 

Increased destruction/sequestration:

-immune injury to cells

-splenomegaly (sequestration)

-increased peripheral use (severe infections)

 

3

What is agranulocytosis?

Decreased levels of neutrophils that there is a clinically significant change of infection.

4

What is the main cause of agranulocytosis?

drug toxicity

5

What is leukophila?

high WBC (~>10,000 cells/mm3)

6

What are the main causes of leukocytosis?

Increased production in marrow:

-chronic infection/inflammation

-paraneoplastic

-myeloproliferative disorders (MPD)

 

Increased release from marrow:

-infection

-hypoxia

 

Decreased margination

-exercise

-catecholamines

 

Decreased extravasation:

-glucocorticoids

7

What are common causes of neutrophilia?

-acute bacterial infections

-sterile inflammation tissue necrosis (ie. MI and burns)

-high cortisol (releases marginated neutrophils)

8

What are common causes of eosinophilia?

-allergies

-parasitic infections

-malignacies

-drug reactions

-autoimmune disorders

9

What are common causes of basophilia?

RARE, think myeloproliferative disorders (MPD/CML)

10

What are common causes of monocytosis?

-chronic infections (granulomatous disease)

-autoimmune disorders

-IBS

11

What are common causes of lymphocytosis?

-with monocytosis

-viral infections

-Bordetella pertussis (prevents lymphocyte entry into LN)