Plasma Cell Disorders (Dyscrasias) Flashcards Preview

SBL Exam 1 WBCs, Spleen, and Thymus > Plasma Cell Disorders (Dyscrasias) > Flashcards

Flashcards in Plasma Cell Disorders (Dyscrasias) Deck (9)
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1

What is the most common plasma cell dyscrasia?

MGUS

2

What is multiple myeloma?

-plasma cell cancer

-rearrangements of the Ig heavy chain (IgG/IgA)

-excessive monoclonal Ig production

-tumor cells produce IL-6, aiding tumor survival

-CD138, CD56, and syndecan-1 (commone plasma cell markers)

3

What is the common presentation of multiple myeloma?

-older adults (median 65-70)

-painful lytic bone lesions with a "punched-out" appearance

-humoral immune dysfunctions

-hypercalcemia

-renal failure

4

What are potential findings/complications of multiple myeloma? (there are several)

-pathologic fractures

-elevated serum protein with M spike

-increased risk of infection, most common COD (due to mass amounts of monoclonal Ab)

-AL amyloidosis (increased Ig light chains)

-renal failure (second most common COD) with Bence Jones protien (Ig light chain found in urine)

-Rouleaux formation of RBCs

 

5

What is the course/prognosis of multiple myeloma?

somewhat aggressive course

 

variable prognosis depending on progression (median survival 4-7 years)

no cure

6

What is solitary myeloma?

mild version of multiple myeloma in which there is only one bony lesion (hence single vs. multiple)

7

What is MGUS?

monoclonal gammopathy of uncertain significance

-asymptomatic elevation of M proteins

8

What is the common presentation of MGUS?

-elderly

-asymptomatic (by definition missing symptoms of MM)

9

Compare multiple myeloma, smoldering myeloma, and MGUS.

MM:

-symptomatic

-bone marrow bioposy >30% plasma cells

->3g/dL serum M protein

-Bence-Jones protein

 

Smoldering myeloma (transition from MGUS to MM; 75%):

-asymptomatic

-bone marrow bioposy 10-30% plasma cells

->3g/dL serum M protein

 

MGUS (1% progress to MM):

-asymptomatic

-<3g/dL serum M protein

-no Bence-Jones protein