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SBL Exam 1 WBCs, Spleen, and Thymus > High Yield > Flashcards

Flashcards in High Yield Deck (20)
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1

What is t(8:14) associated with?

Burkitt lymphoma

(worst lymphoma (8 letters) transormations (14 letters), Burkitt lymphoma is one of the fastest growing tumors)

 

MYC

 

2

What is t(9:22) associated with?

 

Chronic myelogenous leukemia

 

Philadelphia chromosome

BCR-ABL fusion product

3

What is t(15:17) associated with?

Acute promyelocytic leukemia (Acute myeloid leukemia subtye)

Retinoic receptor α (RARα)

Auer rods (Myeloperoxidase (MPO) crystals)

4

What is t(11;14) associated with?

Mantle cell lymphoma

 

cyclin-D1

G1 -> S transition

5

What is t(14;18) associated with?

follicular lymphoma

 

BCL-2

6

What is a "starry sky" appearance associated with?

Burkitt lymphoma

 

Macrophage "stars" eating necrotic cells with background of dense B cells "sky"

7

What is basophila associated with?

Chronic myeloid leukemia

 

basophils are rarely elevated, in CML, there is an over proliferation of all granulocytes, which includes basophils

8

What are Auer rods associated with?

Acute myeloid leukemia

 

Auer rods = aggregates of myeloperoxidase (MPO)

9

What are B signs?

S/x associated with B cell neoplasms

 

consists of generalized symptoms:

-fever

-weight loss

-fatigue

-pain

-night sweats

-pruritis

10

What are dacrocytes ("teardrop cells") most associated with?

Primary myelofibrosis

11

What are smudge cells associated with?

CLL

12

What leukemia/lymphoma are CD5+ B cells associated with?

CLL

13

What leukemia/lymphoma is associated with a marrow fibrosis and a "dry tap".

Hairy cell leukemia

14

What leukemia/lymphoma is associated with overexpression of Bcl-2?

follicular lymphoma

 

t(14;18)

15

What leukemia/lymphpoma is associated with CD15+ and CD30+ cells?

Hodgkin lymphoma

16

What leukemia/lymphoma is NF-κB activation associated with?

Hodgkin lymphoma

 

(frequently but not always through EBV)

17

What type of lymphoma/leukemia is peroxidase associated with?

Myleoid differenitated cell types

18

What type of lymphoma/leukemia is non-specific esterase associated with?

Monocytic differenitated cell types

19

What type of lymphoma/leukemia is BCL-6 most associated with?

diffuse large B-cell lymphoma

20

What type of lymphoma/leukemia is BRAF most associated with?

Hairy cell leukemia