Hormonal Agents: Analogues and Inhibitors (Part 02) Flashcards
(35 cards)
Drugs that mimic or block the effects of hypothalamic and pituitary hormones have pharmacologic applications in three (3) primary areas: (A) As replacement therapy for hormone deficiency states; (B) As antagonists for diseases caused by excess production of pituitary hormones; (C) As diagnostic tools for identifying several endocrine abnormalities.
Hormonal Agents
Two (2) Medicinal GH
- Somatropin
- Somatrem
(T/F): Medicinal GH was isolated from the pituitaries of human cadavers.
T
Medicinal GH is contaminated with prions that could cause __________.
Creutzfeldt-Jakob Disease
Five (5) Uses of Medicinal GH
- Prader-Willi Syndrome
- Turner Syndrome
- Idiopathic Short Stature (ISS)
- Anti-Aging Remedy
- Use by Athletes
An autosomal dominant genetic disease associated with growth failure, obesity, and carbohydrate intolerance.
Prader-Willi Syndrome
Drug/s under Recombinant Human IGF-I / Somatomedins
- Mecasermin
- Mecasermin Rinfabate
Drug/s for the treatment of severe IGF-I deficiency that is not responsive to GH.
- Mecasermin
- Mecasermin Rinfabate
A/E of Recombinant Human IGF-I / Somatomedins
Hypoglycemia
Drug/s for Excessive GH
- Somatostatin
- Octreotide
- Lanreotide
- Pegvisomant
It inhibits the release of GH, TSH, glucagon, insulin, and gastrin.
- Somatostatin
- Octreotide
- Lanreotide
A GH receptor antagonist.
Pegvisomant
A/E of Somatostatin
Hyperglycemia
A/E of Ocreotide and Lanreotide
- Nausea
- Vomiting
- Abdominal Cramps
- Flatulence
- Steatorrhea Vitamin B12 Deficiency
Four (4) Types of Gonadotropin Analogues
- Menotropins
- FSH Analog
- LH Analog
- Human Chorionic Gonadotropin
A human menopausal gonadotropins (HMG). It is extracted from the urine of postmenopausal women. The purified extract of FSH and LH.
Menotropins
A purified preparation of human extracted from the urine of postmenopausal women.
Urofollitropin
Two (2) Recombinant Forms of FSH
- Follitropin Alfa
- Follitropin Beta
Recombinant Form of Human LH
Lutropin Alfa
It has only been approved for use in combination with follitropin alfa for stimulation of follicular development in infertile women with profound LH deficiency.
Lutropin
It is produced by the human placenta and excreted into the urine.
Human Chorionic Gonadotropin
An acetate salt of synthetic human GnRH.
Gonadorelin
Drug/s under GnRH Agonists
- Goserelin
- Histrelin
- Leuprolide
- Nafarelin
- Triptorelin
A syndrome of cyclical abdominal pain in premenopausal women that is due to the estrogen-sensitive endometrium-like tissue in the uterus.
Endometriosis
