Hormones

Question 1

DOC obesity

Answer 1

Liraglutide

Question 2

CHF is a complication of which DPP4 inhibitor

Answer 2

Saxagliptin

Question 3

Risk of hepatitis is increased with which DPP4 inhibitor

Answer 3

Vildagliptin

Question 4

Only gliptin that is excreted through liver and not kidney

Answer 4

Linagliptin

Question 5

Name the amylin analogue

Answer 5

Pramlintide

Question 6

Which drugs can be used in both type one and type two diabetes mellitus?

Answer 6

Pramlintide and insulin

Question 7

Only insulin which is milky cloudy white

Answer 7

Isophane

Question 8

Insulin which has acid pH

Answer 8

Glargine

Question 9

Insulin which forms white crystals with other insulin in same syringe

Answer 9

Glargine

Question 10

Longest acting insulin

Answer 10

Degludec

Question 11

The only insulin for which rate of absorption does not depend on the site of injection is

Answer 11

Glargine

Question 12

Most common site for injection of insulin

Answer 12

Abdomen

Question 13

Drug of choice for diabetic ketoacidosis and route

Answer 13

IV regular insulin

Question 14

Sulfonylurea of choice in elder

Answer 14

Glipizide

Question 15

Pioglitazone decreased insulin resistance by acting on which tissue?

Answer 15

By acting on adipose tissue

Question 16

Side effects of metformin

Answer 16

B12 deficiency due to decreased calcium dependent b 12 absorption

LACTIC ACIDOSIS

Question 17

C/I of Metformin

Answer 17

CHF
Severe lung disease
Renal failure
Hepatic failure
Chronic alcoholics

Question 18

Drugs causing weight loss

Answer 18

GLP1 agonists
Metformin
SGLT2 #
Amylin analogues

Question 19

Which classes of anti diabetic drugs reduce CVS mortality?

Answer 19

GLP1 agonists and SGLT2 #

Question 20

GLP2 agonists name

Answer 20

Teduglutide

Question 21

Most potent steroids

Answer 21

Dexamethasone and betamethasone

Question 22

Least potent steroid

Answer 22

Hydrocortisone

Question 23

Longest acting glucocorticoids

Answer 23

Dexamethasone and betamethasone

Question 24

Shortest acting steroid

Answer 24

Hydrocortisone

Question 25

Most potent topical steroid

Answer 25

Clobetasol propionate ointment

Question 26

Steroids are used in pregnancy for

Answer 26

Surfactant maturation

Question 27

Mechanism of anti-inflammatory and immuno suppressive action of steroids

Answer 27

Decrease the production of inflammatory mediators like I L1 , IL6and TNF alpha Increase production of anti-inflammatory mediators like I 10 and annexin1 Lymphocyte apoptosis as well as cause re-distribution of lymphocytes

Question 28

Only drug to decrease mortality in Covid

Answer 28

Steroids

Question 29

Infections in which steroids can be used

Answer 29

H. Influenza, meningitis, Covid pneumonia.

Question 30

Which drug inhibits bone resorption and stimulates bone formation at the same time?

Answer 30

Strontium ranelate

Question 31

Drugs that stimulate bone formation

Answer 31

Teriparatide, abolaparatide, romosozumab

Question 32

Most potent bisphosphonate

Answer 32

Zoledronate

Question 33

Mechanism of action of second and third generation bisphosphonates

Answer 33

Block Farnesyl pyrophosphate synthase which is required in mevalonate pathway, leading to apoptosis of osteoclasts

Question 34

Mechanism of action of first generation base phosphonates

Answer 34

Abnormal ATP production which cannot be used by osteoclasts leading to the apoptosis

Question 35

What is the advice given to patients on bisphosphonates ?

Answer 35

To prevent esophagitis, patient is advised to take the drug with a full glass of water and not lie down for 30 minutes The same advice is given for patients taking tetracycline

Question 36

Anti sclerostin antibody name

Answer 36

Romosozumab

Question 37

Fastest acting, anti thyroid drugs

Answer 37

Iodide