Hypersensitivies And Immunopathologies

Question 1

MS is associated with what specific hypersensitivity reaction?

Answer 1

T cell mediated cytotoxicity

Question 2

What is the theory that the rise in chronic inflammatory disease, especially allergies and asthma is an unintended consequence of a reduction in exposure to microbes in the first year of life?

Answer 2

Hygiene hypothesis

Question 3

What type of hypersensitivity reaction occurs within minutes or hours?

Answer 3

Type I

Question 4

How is TB contracted?

Answer 4

Airborne infection

Question 5

Cell mediated cytotoxicity is mediated by what?

Answer 5

CD8 killer T cells

Question 6

What is the “anti onco” gene that prevents tumors?

Answer 6

TP53

Question 7

What type of hypersensitivity reaction uses T cells?

Answer 7

Type IV

Question 8

What is released by mast cells in the early phase?

Answer 8

Vasoactive amines (histamine), proteases, prostaglandins

Question 9

What condition is caused by defects in immune regulation ?

Answer 9

Allergy

Question 10

What is the number 2 cause of death?

Answer 10

Cancer

Question 11

What are pathologic conditions caused by a normal immune response?

Answer 11

TB sepsis

Question 12

What gene is an accident waiting to happen?

Answer 12

Proto-oncogene

Question 13

In vitro what cells can destroy some cancer cells?

Answer 13

NK cells

Question 14

Lupus and Rheumatoid arthritis are associated with what type of hypersensitivity ?

Answer 14

Type III

Question 15

What is a mutated chromosome 22 called?

Answer 15

Philadelphia chromosome

Question 16

Will someone always have an initial allergic reaction to the first exposure?

Answer 16

No, it takes a while for the IgE antibodies to accumulate

Question 17

What hypersensitivity reaction is antibody mediated but depend on complement to do the killing?

Answer 17

TYPE II

Question 18

What cells response is delayed during an allergic reaction?

Answer 18

Eosinophils

Question 19

MS is initiated by what?

Answer 19

Self reactive T cells

Question 20

What type of hypersensitivity reaction is known as allergies?

Answer 20

Type I

Question 21

How many mutations are required to produce cancer?

Answer 21

4-7

Question 22

What type of hypersensitivity is stimulated by intracellular parasites?

Answer 22

Type IV

Question 23

Secondary exposure to an allergen will activate what cells?

Answer 23

Mast cells

Question 24

What is MPDL3280A

Answer 24

Manufactured antibody that targets a progestin called PD-L1

Question 25

What is the observation of both tumor inhibiting and tumor enchanting process mediated by the immune system?

Answer 25

Immunoediting hypothesis

Question 26

What is it called when lymphocytes attack non self and SELF?

Answer 26

Molecular mimicry

Question 27

Which type of hypersensitivity reaction is immediate?

Answer 27

Type I

Question 28

What hypersensitivity reaction is antibody mediated?

Answer 28

Type II

Question 29

During an allergic reaction what cells are recruited from bone marrow (t helper secreting IL-5) ?

Answer 29

Eosinophils

Question 30

Do hypersensitivity reactions target self antigens or foreign antigen ?

Answer 30

Either or

Question 31

The Philadelphia chromosome is associated with what?

Answer 31

Chronic myeloid leukemia

Question 32

Is ADCC complement independent or dependent?

Answer 32

Independent

Question 33

What does most of the damage in MS?

Answer 33

Macrophages

Question 34

Hypersensitivity is when the immune response to the antigen is _______or________?

Answer 34

Excessive or inappropriate

Question 35

Lupus erythematosus is what cell intolerance ??

Answer 35

B AND T CELL INTOLERANCE

Question 36

What specific named reaction is associated with Type III hypersensitivity?

Answer 36

Arthus reaction

Question 37

HIV-1 infects what cells?

Answer 37

Help T cells

Question 38

What type of hypersensitivity reaction is associated with inflammation?

Answer 38

Type III

Question 39

What type of hypersensitivity does not involve antibodies?

Answer 39

Type IV

Question 40

What cells during an allergic reaction have an immediate response ?

Answer 40

MAST cells

Question 41

Non atopic people produce mainly what antibody?

Answer 41

IgG

Question 42

Poison ivy is associated with what hypersensitivity ?

Answer 42

Type IV (DTH)

Question 43

What is an example of an immunodeficiency ?

Answer 43

Genetic deficiency and AIDS

Question 44

What causes allergies?

Answer 44

Overproduction of IgE antibodies

Question 45

What type of hypersensitivity reaction uses IgE

Answer 45

Type I

Question 46

What cells also have receptors for IgE and will DEGRANULATE upon antigen exposure

Answer 46

Basophils

Question 47

During pregnancy the mom has a strong bias towards what?

Answer 47

Th2

Question 48

Lupus is more common in who?

Answer 48

Woman, in lungs joints, kidneys

Question 49

What interleukin is associated with class switching?

Answer 49

IL4

Question 50

What is released by mast cells in the late phase?

Answer 50

IL-4, and TNF

Question 51

Allergies are associated with what kind of bias?

Answer 51

Th2

Question 52

What type of hypersensitivity reaction is CELL mediated ?

Answer 52

Type IV

Question 53

What type of hypersensitivity reaction is immune complex mediated?

Answer 53

Type III

Question 54

What antibodies are good at fixing complement?

Answer 54

IgM and IgG

Question 55

Delayed type hypersensitivity is mediated by what?

Answer 55

CD4 helper t cells

Question 56

What hypersensitivty reaction is when antibody antigen complexes accumulate, deposit in tissues and cause inflammation ?

Answer 56

Type III

Question 57

What type of hypersensitivity reaction uses IgM and or IgG?

Answer 57

Type II

Question 58

What cytokine is assocaited with Sepsis?

Answer 58

TNF

Question 59

What type of hypersensitivity reaction uses IgM and or IgG?

Answer 59

Type III

Question 60

What are examples of functional derangements?

Answer 60

Myasthenia gravis, pernicious anemia, graves disease.