Hypersensitivies And Immunopathologies Flashcards Preview

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Flashcards in Hypersensitivies And Immunopathologies Deck (60)
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1

MS is associated with what specific hypersensitivity reaction?

T cell mediated cytotoxicity

2

What is the theory that the rise in chronic inflammatory disease, especially allergies and asthma is an unintended consequence of a reduction in exposure to microbes in the first year of life?

Hygiene hypothesis

3

What type of hypersensitivity reaction occurs within minutes or hours?

Type I

4

How is TB contracted?

Airborne infection

5

Cell mediated cytotoxicity is mediated by what?

CD8 killer T cells

6

What is the "anti onco" gene that prevents tumors?

TP53

7

What type of hypersensitivity reaction uses T cells?

Type IV

8

What is released by mast cells in the early phase?

Vasoactive amines (histamine), proteases, prostaglandins

9

What condition is caused by defects in immune regulation ?

Allergy

10

What is the number 2 cause of death?

Cancer

11

What are pathologic conditions caused by a normal immune response?

TB sepsis

12

What gene is an accident waiting to happen?

Proto-oncogene

13

In vitro what cells can destroy some cancer cells?

NK cells

14

Lupus and Rheumatoid arthritis are associated with what type of hypersensitivity ?

Type III

15

What is a mutated chromosome 22 called?

Philadelphia chromosome

16

Will someone always have an initial allergic reaction to the first exposure?

No, it takes a while for the IgE antibodies to accumulate

17

What hypersensitivity reaction is antibody mediated but depend on complement to do the killing?

TYPE II

18

What cells response is delayed during an allergic reaction?

Eosinophils

19

MS is initiated by what?

Self reactive T cells

20

What type of hypersensitivity reaction is known as allergies?

Type I

21

How many mutations are required to produce cancer?

4-7

22

What type of hypersensitivity is stimulated by intracellular parasites?

Type IV

23

Secondary exposure to an allergen will activate what cells?

Mast cells

24

What is MPDL3280A

Manufactured antibody that targets a progestin called PD-L1

25

What is the observation of both tumor inhibiting and tumor enchanting process mediated by the immune system?

Immunoediting hypothesis

26

What is it called when lymphocytes attack non self and SELF?

Molecular mimicry

27

Which type of hypersensitivity reaction is immediate?

Type I

28

What hypersensitivity reaction is antibody mediated?

Type II

29

During an allergic reaction what cells are recruited from bone marrow (t helper secreting IL-5) ?

Eosinophils

30

Do hypersensitivity reactions target self antigens or foreign antigen ?

Either or