Immune System Dysreg Flashcards
(28 cards)
What pathologies are caused by a normal condition ?
Tb, sepsis
What conditions caused by defects in the immune regulation?
Allergy
What are diseases that are immunodeficiency ?
AIDS, genetic deficiency
Molecular mimicry is associated with what?
Autoimmune disease
How is TB contracted ?
Airborne infection
When TB organism is inhaled it is engulfed by what?
Alveolar macrophages (dust cells)
What does vitamin D release that increase antimicrobial activity against TB?
Cathelicidins
What is a potentially life threating complication of an infection?
Sepsis
Sepsis occurs when chemicals released into the blood to wfight the infection trigger what?
Inflammation throughout the body
What cytokine is associated with sepsis?
TNF
In sepsis TNF does what to vascular permeability and blood volume and BP?
Decreases, causing septic shock and heart failure
In sepsis vagal stimulation decreases what?
Macrophage release of TNF
Allergies are associated with a bias towards what?
Th2
Non allergic people produce what antibody and have what kind of bias?
IgG and Th1
People with an allergy produce large quantities of what and have what bias?
IgE and Th2
Fc end of IgE binds to what?
Mast cells
Fab end of IgE binds to allergen which triggers what?
Mast cell to degranulation
What interleukin can recruit many eosinophils from bone marrow ?
IL-5
What acts as a guidance system for mast cells basophils and eosinophils?
IgE
The placenta produces large quantities of what?
IL-4
Is it better for the fetus to be bias towards Th1 or Th2?
Th2
What activates NK cells?
TNF
What is the theory that the use of chronic inflammation diseases, especially allergies and asthma, is an unintended consequence of a reduction in exposure to microbes in the first years of life?
Hygiene hypothesis
People who are atopic are more likely to have inherited what genes?
Class II MCH
