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Flashcards in Immune System Dysreg Deck (28)
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1

What pathologies are caused by a normal condition ?

Tb, sepsis

2

What conditions caused by defects in the immune regulation?

Allergy

3

What are diseases that are immunodeficiency ?

AIDS, genetic deficiency

4

Molecular mimicry is associated with what?

Autoimmune disease

5

How is TB contracted ?

Airborne infection

6

When TB organism is inhaled it is engulfed by what?

Alveolar macrophages (dust cells)

7

What does vitamin D release that increase antimicrobial activity against TB?

Cathelicidins

8

What is a potentially life threating complication of an infection?

Sepsis

9

Sepsis occurs when chemicals released into the blood to wfight the infection trigger what?

Inflammation throughout the body

10

What cytokine is associated with sepsis?

TNF

11

In sepsis TNF does what to vascular permeability and blood volume and BP?

Decreases, causing septic shock and heart failure

12

In sepsis vagal stimulation decreases what?

Macrophage release of TNF

13

Allergies are associated with a bias towards what?

Th2

14

Non allergic people produce what antibody and have what kind of bias?

IgG and Th1

15

People with an allergy produce large quantities of what and have what bias?

IgE and Th2

16

Fc end of IgE binds to what?

Mast cells

17

Fab end of IgE binds to allergen which triggers what?

Mast cell to degranulation

18

What interleukin can recruit many eosinophils from bone marrow ?

IL-5

19

What acts as a guidance system for mast cells basophils and eosinophils?

IgE

20

The placenta produces large quantities of what?

IL-4

21

Is it better for the fetus to be bias towards Th1 or Th2?

Th2

22

What activates NK cells?

TNF

23

What is the theory that the use of chronic inflammation diseases, especially allergies and asthma, is an unintended consequence of a reduction in exposure to microbes in the first years of life?

Hygiene hypothesis

24

People who are atopic are more likely to have inherited what genes?

Class II MCH

25

What blocks the binding of IgE to mast cells?

Xolair

26

What interleukin are associated with Th2?

IL-4, IL-5, IL-13

27

What is an immune system attack on myelin in PNS?

Gillian barre

28

What is an inflammatory process of the spinal cord, and can cause axon demyelination?

Transverse myelitis