Cancer

Question 1

Cancer arises when multiple controls systems are corrupted within__________?

Answer 1

A single cell

Question 2

What gene is an accident waiting to happen ?

Answer 2

Proto oncogene

Question 3

What is an oncogen ?

Answer 3

Mutated

Question 4

What gene is the anti oncogene?

Answer 4

TP53

Question 5

How many mutations are required for most cancers?>

Answer 5

4-7

Question 6

The philadelphia chromosome is associated with what?

Answer 6

Chronic myeloid leukemia

Question 7

What chromosome is known as the Philadelphia chromosome ?

Answer 7

22

Question 8

HHv-8 + AIDS =

Answer 8

Karpsi sarcoma

Question 9

HPV = what cancer ?

Answer 9

Cervical

Question 10

Liver cancer =

Answer 10

Chronic hep B

Question 11

What is the overseeing of both tumor inhabiting and tumor enhancingc processes mediated by the immune system ?

Answer 11

Immunoediting hypothesis

Question 12

Can hyperacticated macrophages kill cancer?

Answer 12

Yes via, TNF

Question 13

In Vivo what cell can be effective against cancer?

Answer 13

NK cells

Question 14

N1 phenotype =

Answer 14

Antitumorigenic

Question 15

N2 phenotype =

Answer 15

Pro tumorigenic

Question 16

What protein in rats is deficient making them more Likely to developed tumors?

Answer 16

RAG-2

Question 17

How can cancer cells disable CTLs?

Answer 17

Express high levels of indoleamine 2,3 deoxygenase

Question 18

In what kind of cancer are vaccines used to prevent it?

Answer 18

Viral (hep b, HPV)

Question 19

What is associated with the immune checkpoint blockade ?

Answer 19

Yervoy (ipillimumab) and the CTLA-4 receptor

Question 20

What is MPDL3280A ?

Answer 20

Immune therapy against cancer that targets protein called PD-L1

Question 21

What are infections of step that cause regression of sarcoma?

Answer 21

Coleys toxins

Question 22

Injecting what will cause macrophages to become hyperactive which will destroy tumors?

Answer 22

Bacille Calmette-guerin (BCG