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Flashcards in Cancer Deck (22)
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1

Cancer arises when multiple controls systems are corrupted within__________?

A single cell

2

What gene is an accident waiting to happen ?

Proto oncogene

3

What is an oncogen ?

Mutated

4

What gene is the anti oncogene?

TP53

5

How many mutations are required for most cancers?>

4-7

6

The philadelphia chromosome is associated with what?

Chronic myeloid leukemia

7

What chromosome is known as the Philadelphia chromosome ?

22

8

HHv-8 + AIDS =

Karpsi sarcoma

9

HPV = what cancer ?

Cervical

10

Liver cancer =

Chronic hep B

11

What is the overseeing of both tumor inhabiting and tumor enhancingc processes mediated by the immune system ?

Immunoediting hypothesis

12

Can hyperacticated macrophages kill cancer?

Yes via, TNF

13

In Vivo what cell can be effective against cancer?

NK cells

14

N1 phenotype =

Antitumorigenic

15

N2 phenotype =

Pro tumorigenic

16

What protein in rats is deficient making them more Likely to developed tumors?

RAG-2

17

How can cancer cells disable CTLs?

Express high levels of indoleamine 2,3 deoxygenase

18

In what kind of cancer are vaccines used to prevent it?

Viral (hep b, HPV)

19

What is associated with the immune checkpoint blockade ?

Yervoy (ipillimumab) and the CTLA-4 receptor

20

What is MPDL3280A ?

Immune therapy against cancer that targets protein called PD-L1

21

What are infections of step that cause regression of sarcoma?

Coleys toxins

22

Injecting what will cause macrophages to become hyperactive which will destroy tumors?

Bacille Calmette-guerin (BCG