Flashcards in Cancer Deck (22)
Cancer arises when multiple controls systems are corrupted within__________?
A single cell
What gene is an accident waiting to happen ?
What is an oncogen ?
What gene is the anti oncogene?
How many mutations are required for most cancers?>
The philadelphia chromosome is associated with what?
Chronic myeloid leukemia
What chromosome is known as the Philadelphia chromosome ?
HHv-8 + AIDS =
HPV = what cancer ?
Liver cancer =
Chronic hep B
What is the overseeing of both tumor inhabiting and tumor enhancingc processes mediated by the immune system ?
Can hyperacticated macrophages kill cancer?
Yes via, TNF
In Vivo what cell can be effective against cancer?
N1 phenotype =
N2 phenotype =
What protein in rats is deficient making them more Likely to developed tumors?
How can cancer cells disable CTLs?
Express high levels of indoleamine 2,3 deoxygenase
In what kind of cancer are vaccines used to prevent it?
Viral (hep b, HPV)
What is associated with the immune checkpoint blockade ?
Yervoy (ipillimumab) and the CTLA-4 receptor
What is MPDL3280A ?
Immune therapy against cancer that targets protein called PD-L1
What are infections of step that cause regression of sarcoma?