Hypersensitivity 3 Flashcards
What is recognised as foreign during a transplant?
MHC
Which cell does not have MHCI?
RBCs
What recognises a donor organ’s MHC as foreign?
T cell
What is transplant donor tissue killed off by?
Cytotoxic t cells, Th cells and antibodies
What steps are taken to mitigate transplant rejection?
Blood and tissue typing
Matching MHC haplotypes
What could happen if t cells are transplanted into a recipient?
The transplanted t cells could start to attack the recipients tissues
WHich antigen does everyone have on the surface of their RBCs?
Glycolipid antigen (O)
What are the carbohydrate groups that are joined to the glycolipid antigen on RBCs?
A or B
WHich antibodies do group A blood people have?
Anti B antibodies
Which antibodies do group B blood people have?
Anti B antibodies
Which antibodies do group O blood people have?
Anti A and anti B
Which antibodies do group AB blood people have?
None
Why do AB people not produce antibodies aginst blood?
Need to recognise both antigens
What must a blood recipient not have?
Antibodies against the blood the are receiving
Universal blood donor?
O-
Universal blood recipient?
AB
What other blood antigen is taken into account?
Rhesus factor D
what does the + or - mean for blood type?
+ve or -ve for rhesus factor d
What % of the population are rhesus factor d positive?
85%
Which people have antibodies against the rhesus d factor?
Rhesus -ve people
What is not transferred during blood transfusion?
Plasma
What is transferred during a blood transfusion?
RBCs
Meaning of weakly immunogenic?
The thing doesnt stimulate a strong immune response
How immunogenic are tumours?
Not very
