HYPERSENSITIVTY

Question 1

it is an exaggerated response to a harmless antigen that results in injury t the tissue, disease, or even death

Answer 1

Hypersensitivity reaction

Question 2

antigens that triggers type 1 hypersensitivity

Answer 2

Allergen

Question 3

type of hypersensitivity reaction that has complement involvement

Answer 3

Type 2 and type 3

Question 4

t/f

Type 1 hypersensitivity requires 2 exposures to the allergen

Answer 4

true

Question 5

examples of type 1 hypersensitivty

Question 6

examples for type 2 hypersensitivity

Question 7

examples for type 3 hypersensitivity

Answer 7

dengue
farmers lungs
—-

Question 8

characterized by severe itching, erythema, caused by localized vasodilation, leakage of fluid into the surrounding area, and a spreading area of reddness

Answer 8

Urticaria/ hives

Question 9

“panting” or breathlessness” caused by inhalation of small particles such as pollen, dust, or fumes

Answer 9

asthma

Question 10

laboratory testing for type 1 hypersensitivity

Answer 10

-in vivo skin test
>cutaneous and intradermal
-in vitro test
>rist
>rast

Question 11

a competitive RIA test for Total IgE

Answer 11

Rist (radio immunosorbent test)

Question 12

a non-competitive RIA test for specific IgE

Answer 12

RAST (radio allergosorbent test)

Question 13

test for type II hypersensitivity

Answer 13

DAT
IAT

Question 14

examples of B cell deficiency

Answer 14

-transient hypogammaglobulinemia of infancy
-selective IgA = most common immunodeficiency
-burtons x-linked
-hyper Igm
-Hyper IgE
-isolated IgG subclass deficiency

Question 15

Immunodeficiency relating to T cells

Answer 15

-DiGeorge syndrome
-purine neucleoside phosphorylase deficiency

Question 16

Immunodeficiencies of combined B and T cells

Answer 16

-severe combined immunodeficiency
-bare lymphocyte
-x linked-scid
-adenosine deaminase
-wiskot-aldrich
-ataxia telangeictasia

Question 17

immunodeficiencies of phagocytic function

Answer 17

-CGD
-chediak- higashi
-leukocyte adhesion

Question 18

absence of BTK gene (burton’s tyrosine kinase
-immature B cells will not mature because of lack of enzyme

Answer 18

Burton’s X-linked agammaglobulinemia

Question 19

-failure of mature B cells to become plasma cells
-decrease IgA and IgG

Answer 19

Common Variable Immunodeficiency
(CVI)

Question 20

-failure of B cells to produce antibodies due to delayed maturation of thymus
-aslo referred to ad Pediatric hypogammaglobulinemia

Answer 20

Transient Hypoagammaglobulinemia

Question 21

CD40 present on the surface of B cells will react with CD40 ligand on T helper cells to initiate class switching of IgM to IgG

Answer 21

IgM- IgG switching

Question 22

Increase levels of IgM
-absence of CD40 ligand on T helper Cell

Answer 22

X-linked Hyper IgM syndrome

Question 23

impaired IL-2 production
-hyperactive Th2
-prone to allergic reaction

Answer 23

Hyper IgE

Question 24

-most common primary immunodeficiency
-failure of B cell to become IgA-producing plasma cells

Answer 24

IgA deficiency

Question 25

-Person lacking a specific IgG subclass -vulnerable to certain kinds of infection

Answer 25

Isolated IgG subclass deficiency

Question 26

a developmental abnormality of the third and fourth pharyngeal pouches that affects thymic development -absence of chromosome 22q

Answer 26

DiGeorge Synrome/anomaly

Question 27

-accumulation of deoxyguanosine triphosphate which is toxic to immature T lymphocytes in the thymus

Answer 27

Purine-nucleoside phosphorylase deficiency

Question 28

Abnormality in integral membrane (CD43); gene responsible for defect TRIAD of WAS -eczema -thrombocytopenia -immunodeficiency

Answer 28

Wiskott-Aldrich Syndrome

Question 29

-aka louis-bar syndrome is a neurodegenerative inherited disorder -absence of ATS gene which codes for ATM protein

Answer 29

Ataxia- Telangiectasia Syndrome

Question 30

Absence of NADPH oxidase

Answer 30

Chronic granulomatous Disease

Question 31

Absence of LYST gene (lysosomal trafficking) which codes for LYST protein -albinism: transport of melanin to melanocytes fail

Answer 31

Chediak-Higashi syndrome

Question 32

HLA associate with Systemic Lupus Erythematosus

Answer 32

HLA-DR2 HLA- DR3

Question 33

HLA associate with Rheumatoid Arthritis

Answer 33

HLA-DR1 HLA-DR4

Question 34

HLA associate with Hashimoto's thyroiditis

Answer 34

HLA-DR4 HLA- DR5