Hypoproliferative anemias Flashcards Preview

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Flashcards in Hypoproliferative anemias Deck (27):
1

Lab signs of hypoproliferative anemia?

anemia
low RC

2

Why is hypersplenism causes in hypoproliferative anemia?

takes on rose of extramedullary hematopoiesis

3

Stem cell disorders w/pancytopenia DD?

aplastic anemia
PNH

4

Ineffective hematopoiesis w/pancytopenia DD?

MDS
megaloblastic anemia

5

Marrow infiltration w/pancytopenia DD?

leukemia/lymphoma
metastatic carcinoma
myelofibrosis

6

Splenic sequestration w/pancytopenia DD?

leukemia/lymphoma
MPNs
storage disorders
Portal hypertension

7

Drugs/tx w/pancytopenia DD?

chem/rad
immunosuppression
other

8

PB changes in megaloblastic anemia?

hypersegments PMNs
macrocytic anemia with oval macrocytes
anisopoikilocytosis

9

BM changes in megaloblastic anemia?

hypercelllularity
giant bands
muclear to cytoplasmic dyssynchrony (megaloblastic change) in erythroids, grans

10

What effect does 5-FU (5-fluorouracil) have on purine synthesis?

inhibits thymidylate synthesis

11

What do chief cells secrete?

Acid

12

What do parietal cells secrete?

intrinsic factor

13

Causes of vitamin B12 deficiency

impared absorption
-IF deficiency, ileal resection, pancreatic insuff
increased req
decreased intake
tapeworm

14

Symptoms of pernicious anemia?

megaloblastic anemia
demyelination/parasthesias/other neurologic effects

15

Most common reason for IF problem?

autoantibodies against IF (req for dx of pernicious anemia)

16

Vit B12 def labs

low vitB12
low RC
autoantibodies to IF or parietal cells
elevated methylmlonic acid

17

Causes of folate deficiency

decreased intake (EtOH, poverty)
increased reqs (growth, pregnancy)
defective absorption
-jejunal resection, malabsorption
folic acid antagonists

18

Symptoms of folate deficiency?

megaloblastic anemia
neural tube defects (spina bifida, anencephaly)

19

Can you treat a B12 deficiency with folate?

no, anemia will reverse but neuro prolems will not

20

DD fro microcytic hypochromia anemia?

IDA
thalassemia
ACD

21

Causes of iron deficiency?

dietary lack
imparied absorption
increaed req
chronic blood loss (GI, menstrual)

22

Another name for hte transferrin receptor?

CD71

23

How to dx IDA?

microcytic, hypochromic anemia
iron studies (esp serum ferritin <12ugL)

24

Iron stduies for IDA

RC decreased
Marrow Iron decreased
Serum ferritin decreased
Serum iron decreased
TIBC increased
% sat decreased

25

Iron studies for thalassemia

RC increased or decreased
Marrow Iron no change/increased
Serum ferritin no change/increased
Serum iron no change/increased
TIBC no change/decreased
% sat no change/increased

26

Iron studies for ACD

RC decreased
Marrow Iron increased
Serum ferritin increased
Serum iron decreased
TIBC no change/decreased
% sat no change/increased

27

How long does it take to find increased reticulocytes in the blood?

5-7 days