Flashcards in Tuesday Groupings/Definitions/Presentations Deck (67)
What are the 4 myeloproliferative neoplasms we know?
What are the categories of myeloid neoplasms?
What is MPN (myeloproliferative neoplasm)?
clonal hematopoietic stem cell disorders
proliferation of one of more of the myeloid lineages
What is similar and different about MPN vs MDS?
similar: hypercellular BM
different: MPN-cytoses, increased cell proliferation, aka effective hematopoiesis, MDS-cytopeniass, increased cell death, aka ineffective hematopoeisis
What is MDS (myelodysplastic syndrome)?
clonal hematopoietic stem cell disorder
cytopenias, dysplasia, ineffective hematopoiesis
What does MPN have the potential to develop to?
BM fibrosis or acute leukemia
What does MDS hav the potential to develop to?
AML (30% of cases)
What percentage of blasts are found in MDS?
What kills with MDS?
infection or bleeding
Median survival of MDS?
What is acute leukemia?
neoplastic proliferation of immature cells (blasts) recapitulating progenitor cells of the hematopoietic system
Acute vs Chronic leukemias
acute-immature cells, untreated live weeks to months
chronic-mature cells, untreated live months to years
AML vs ALL
What is AML (acute myeloid leukemia)?
heterogenous, poor outcome
systemic neoplasms of myeloid progenitor cells
>20% blasts in the blood or marrow
AML types and prognoses
AML w/recurrent cytogenic abnormalities-favorable
AML w/myelodysplasia associated chagnes-poor
Feature of histiocytic conditions?
very high ferratin
What are the 3 phases of CML?
Blast phase (3-6mo)
What is the leukematoid reaction? Types and causes?
exaggerated resonse to infection
eosinophilic-cutaneous larva migrans
What is the leukoerythroblastic reacton?
immature bone cells in the PB
What causes leukoerythroblastic rxns?
bone marrow fibrosis
severe bone marrow stress
Neutrophilia counts and causes?
sterile infl w/necrosis
What drugs cause neutrophilia?
Neutropenia counts and causes?
Eosinophilia counts and causes?
Type 1 HSN
Basophilia counts and causes?
chronic kidney disease
Clinical pres for MPN
CML counts? penias/cytoses?
thrombotic events due to hyperviscosity
signs of increased histamine
PV lab findings?
increased RBC mass