Tuesday Groupings/Definitions/Presentations Flashcards Preview

Heme/Lymph > Tuesday Groupings/Definitions/Presentations > Flashcards

Flashcards in Tuesday Groupings/Definitions/Presentations Deck (67)
Loading flashcards...
1

What are the 4 myeloproliferative neoplasms we know?

CML
PV
PMF
ET

2

What are the categories of myeloid neoplasms?

MPN
MDS
AML

3

What is MPN (myeloproliferative neoplasm)?

clonal hematopoietic stem cell disorders
proliferation of one of more of the myeloid lineages

4

What is similar and different about MPN vs MDS?

similar: hypercellular BM
different: MPN-cytoses, increased cell proliferation, aka effective hematopoiesis, MDS-cytopeniass, increased cell death, aka ineffective hematopoeisis

5

What is MDS (myelodysplastic syndrome)?

clonal hematopoietic stem cell disorder
cytopenias, dysplasia, ineffective hematopoiesis

6

What does MPN have the potential to develop to?

BM fibrosis or acute leukemia

7

What does MDS hav the potential to develop to?

AML (30% of cases)

8

What percentage of blasts are found in MDS?

<20%

9

What kills with MDS?

infection or bleeding

10

Median survival of MDS?

9-29mo

11

What is acute leukemia?

neoplastic proliferation of immature cells (blasts) recapitulating progenitor cells of the hematopoietic system

12

Acute vs Chronic leukemias

acute-immature cells, untreated live weeks to months
chronic-mature cells, untreated live months to years

13

AML vs ALL

AML-adults
ALL-kiddos

14

What is AML (acute myeloid leukemia)?

heterogenous, poor outcome
systemic neoplasms of myeloid progenitor cells
>20% blasts in the blood or marrow

15

AML types and prognoses

AML w/recurrent cytogenic abnormalities-favorable
AML w/myelodysplasia associated chagnes-poor

16

Feature of histiocytic conditions?

very high ferratin

17

What are the 3 phases of CML?

Chronic (3-5yr)
Acute (1-2yr)
Blast phase (3-6mo)

18

What is the leukematoid reaction? Types and causes?

exaggerated resonse to infection
WBC >50,000
PMN-appendicitis
lymphocytic-whooping cough
eosinophilic-cutaneous larva migrans

19

What is the leukoerythroblastic reacton?

immature bone cells in the PB

20

What causes leukoerythroblastic rxns?

bone marrow fibrosis
metastatic cancer
severe bone marrow stress

21

Neutrophilia counts and causes?

>7000
infection
sterile infl w/necrosis
drugs

22

What drugs cause neutrophilia?

G-CSF
steroids
catecholamines
lithium

23

Neutropenia counts and causes?

<1500
aplastic anemia
immune destruction
septic shock
chemo

24

Eosinophilia counts and causes?

>700
Type 1 HSN
invasive helminths
hypocortisolism
neoplasms

25

Basophilia counts and causes?

>200
chronic kidney disease
CML

26

Clinical pres for MPN

5th-7th decade
splenomegaly and/orhepatomegaly

27

CML counts? penias/cytoses?

>100,000
Basophilia!!!!
neutrophilia
thrombocytosis
granulocytic hyperplasia

28

PV presentation?

splenomegaly
thrombotic events due to hyperviscosity
signs of increased histamine

29

PV lab findings?

increased RBC mass
decreased EPO
normal SaO2

30

BM with PV?

hypercellular with erythroid hyperplasia