I - Cell Injury, Cell Death and Adaptations Flashcards Preview

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Flashcards in I - Cell Injury, Cell Death and Adaptations Deck (48)
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32

Histochemical reaction used to identify hemosiderin.

Prussian blue test(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

33

Abnormal calcium deposition occuring in the absence of calcium metabolic derangements.

Dystrophic calcification.(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

34

Calcium deposition in normal tissues occuring in the presence of hypercalcemia.

Metastatic calcification (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

35

Grossly seen as fine white granules or clumps, often felt as gritty deposits. Histologically, intra/extracellular basophilic deposits.

Calcium salts(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.27

36

A result of a progressive decline in the proliferative capacity and lifespan of cells.

Cellular aging(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.29

37

Appears as round or oval masses with intensely eosinophilic cytoplasm, nuclei with various stages of chromatin condensation and aggregation, karyorrhexis.

Apoptotic cell(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.20

38

Membrane bound vesicles of cytosol and organelles quickly extruded and phagocytosed without eliciting inflammatory response.

Apoptotic bodies(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.20

39

Clear vacuoles within parenchymal cells, displacing the nucleus to the cell periphery.

Fatty change (TOPNOTCHRobbins Basic Pathology, 8th ed. p.24

40

Focal, intracellular fat deposits creating alternating bands of yellowed myocardium with alternating bands of darker red-brown uninvolved heart or "tigered effect".

Fatty change of the heart(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.24

41

Rounded, eosinophilic accumulation of newly synthesized immunoglobulins in the rough ER of plasma cells.

Russel bodies(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.25

42

Eosinophilic cytoplasmic inclusion in liver cells composed of aggregated intermediate filaments which resist degradation. Seen in patients woth alcoholic liver disease.

Mallory body / "alcoholic hyalin"(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.25

43

Aggregated protein inclusions that contain microtubule-associated proteins and neurofilaments, reflecting disrupted neuronal cytoskeleton.

Neurofibrillary tangles in Alzheimer's disease(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

44

An insoluble brownish-yellow granular intracellular material that accumulates as a function of age and atrophy. Appears as perinuclear electron-dense granules on electron microscopy.

Lipofuschin(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.26

45

A form of tissue necrosis in which the component cells are dead but the basic tissue architecture is preserved. The affected tissues take on a firm texture.

Coagulative necrosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

46

Refers to focal areas of fat destruction, typically resulting from release of activated pancreatic lipases into the substance of the pancreas and the peritoneal cavity. The foci of necrosis contain shadowy outlines of necrotic fat cells with basophilic calcium deposits, surrounded by an inflammatory reaction.

Fat necrosis (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.11

47

A special form of necrosis usually seen in immune reactions involving blood vessels. Deposits of immune complexes, together with fibrin that has leaked out of vessels, result in a bright pink and amorphous appearance in H&E stains, called "fibrinoid" (fibrin-like) by pathologists.

Fibrinoid necrosis (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.11

48

Seen in focal bacterial or, occasionally, fungal infections, because microbes stimulate the accumulation of inflammatory cells and the enzymes of leukocytes digest the tissue.

Liquefactive necrosis (TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10

49

This term is usually applied to a limb, generally the lower leg, that has lost its blood supply and has undergone coagulative necrosis involving multiple tissue layers.

Gangrenous necrosis(TOPNOTCH)Robbins Basic Pathology, 8th ed. p.10