IDR block 4b Flashcards
(54 cards)
EBNA-1,2,3 causes what? These genes are considered latent/lytic or both?
Oncogenic cells and lymphomas Both latent and lytic
Ebstein Barr Virus
If there is splenic rupture, Guillan Barre Syndrome, or meningoencephalitis, what herpes sequeale are we working with most likely in an immuncompromised patient?
Kissing disease, infectious Mononucleosis, EBV
What is a big tip off that infectious mononucleosis has been contracted?
Exudative Pharyngotonsilitis
What herpes sequela is seen below? What must most patients have or be in order to have this disease?
Oral Hairy Leukoplakia Immuncompromised
Burkitts Lymphoma, is usually caused by what? Will normally have what with it?
Herpes Sequeale, more TH2 response versus TH1, Eukaryotic parasites
What translocation is important for Burkitts Lymphoma? What gene is constantly turned on due to gene problem?
8 to 14 C-myc
EBV Lymphoproliferative Disease is caused by a lack of what in the human body?
IFN gamma, TNF alpha, T cell depleted Bone marrow
EBV makes too many what? What is picture indicative thereof?
Antibodies
EBV
What does the Recognition of Paul-Bunnell antigen indicate on agars?
What is the first thing that is attacked on the EBV antigens?
Is there a good treatment?
The presence of heterophile antibodies, production of heterophile antibodies
VCA-IgM
No good treatment
Kaposi’s sarcoma-associated herpes virus (KSHV) is what type of herpes?
What is the numerical notation of KSHV?
Gamma Herpes Virus
HHV-8
What does Kaposi’s Sarcoma-associated herpes virus rash look like?
What population will this show up the most in?
Barton Hesalea
Immuncompromised patients
Beta Herpesvirus encompasses what viruses?
Of the the viruses, which one can cross the placenta?
What is the respective number?
CMV
HHV-5, CMV
HHV-6, HH-7 (Roselia, big rash, fever, and self resolves)
How is CMV moved from patient to patient? Provided it can be held latent in T-Cells and Macrophages
Repression of what immune system piece causes CMV to proliferate?
Blood and tissue secretion
Cell mediated Immunity
CMV and EBV present with very similar symptoms, what is a good way to tell them apart?
CMV will not have the crazy proliferation of B cells
The baby is born as seen in the picture? What disease does the baby have, assuming a viral infection, and what other symptoms can be expected?
Congenital CMV
Microcephaly, Underweight, and Mental Retardation
What is evidence of a post natal baby infection, Congenital CMV infection?
What does CMV look like on a histology slide?
What other test can be used?
Mononucleosis features, Pneumonia, Hepatitis, and Deafness
Owls eyes, large inclusion bodies
PCR
What does Ganciclovir do differently than ACV?
Which is more toxic?
Ganciclovir is activated via a different protein kinase
Ganciclovir is more toxic
What do Ganciclovir, Valganciclovir, and Cidofovir all do?
What does Foscarnet do?
Prodrugs that are converted via a protein kinase, nucleotide analog
Foscarnet, is an altered phosphate group
What symptoms would an immuncompromised patient have with a CMV virus?
Penumonia, meningitis, Exophagitis, Colitis, and Hepatitis
What is another way to double check for the mono virus? (via a lab test)
Heterophile-positive mononucleosis syndrome
What kind of glycoproteins are made for HBV?
HBsAG is what?
S, M, L glycoproteins
Surface protein for Hepatitis
What is the polymerase P and X (proteins, used for)?
Polymerase P is the traditional reading frame, takes mRNA into HBsAg, HBeAg, and HBcAg not mention Reverse Transcriptase activites that replicate Hep B DNA viruses
Polymerase X does transcription and pushes pieces of DNA into human genome
Subviral lipoproteins do not contain any what?
Nucleic Acid
What is the number one viral cause of congenital defects?
Can cause Seizures, Deafness, Jaundice
CMV
