IF7: Chronic inflammation

Question 1

What are the effects of chronic inflammation?

Answer 1

Low grade pyrexia
Cachexia
Mononuclear cell infiltration & proliferation
Tissue cell proliferation that resemble attempts of repair
Leukocytosis
Acute phase response
Anaemia

Question 2

What is acute phase response?

Answer 2

The chronic production of C-reactive proteins.

Question 3

What is the mechanism for anaemia?

Question 4

What are the main cells involved in chronic inflammation?

Answer 4

NK cells, macrophages, dendritic cells, T cells, B cells, monocytes

Question 5

What does ADCC stand for?

Answer 5

Antibody-Dependent Cell-mediated Cytotoxicity

Question 6

What cells are involved in ADCC?

Answer 6

Plasma cells for putting a “tag” on infected cells
NK cells & macrophages for killing infected cells

Question 7

What is a foreign body reaction?

Answer 7

An inflammatory reaction mediated by macrophages since the stimulus is not antigenic. Pro-inflammatory cytokines are secreted and recruit lymphocytes. Persistent macrophage & lymphocyte activity leads to persistent scarring.

Question 8

What are granulomas?

Answer 8

A tight collection of mononuclear cells, mostly monocytes.

Question 9

How are granulomas formed?