Immune System and Inflammation Flashcards Preview

Week 2 > Immune System and Inflammation > Flashcards

Flashcards in Immune System and Inflammation Deck (9)
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1

Key function of immune system

Body's defence system

2

Innate immunity

Mediates the initial protection against infections
First line of defense
Deployed very quickly

3

Adaptive immunity

Mediates the later resonse when needed/required
More effective than innate
Specificity and memory
Develops more slowly (days to weeks)

4

4 key players in the INNATE immune system

Neutrophils
Natural killer cells
Macrophages
Complement system

5

2 key cell types in ADAPTIVE immune system

T cells
B cells

6

4 cardinal signs of inflammation

Heat
Redness
Pain
Swelling
(loss of function)

7

3 key principles of inflammation

Vascular reaction (vasodilation and increased permeability)
Cellular response (specific cell recruitment and activation)
Activated by mediators (derived from plasma proteins and cell types, ex: cytokines)

8

5 major steps of the inflammatory response (5R)

1. Recognition of the injurious/toxic agent
2. Recruitment of WBCs
3. Removal of the toxic agent
4. Regulation (control) of the response
5. Resolution/repair

9

3 key complement pathways and what they are initiated by

Classical (Abs binding to antigens)
Alternative (complement proteins deposited on microbial surface)
Lectin (MBL binds to mannose residues on surface glycoproteins of microbes)