Immunity Review Questions

Question 1

What does the Fc region of an antibody bind to?

Answer 1

Fc receptors on immune cells

Question 2

The Fc region of an antibody mediates functions such as?

Answer 2

• Opsonization
• Complement activation

Question 3

What does the Fab region of an antibody bind to?

Answer 3

Specific antigen

Question 4

This immunoglobulin crosses placenta

Answer 4

IgG

Question 5

This immunoglobulin has a pentameric structure with J chain

Answer 5

IgM

Question 6

This immunoglobulin is found in the serum and body secretions

Answer 6

IgA

Question 7

This immunoglobulin’s Fc binds to receptors on the mast cells, and basophils

Answer 7

IgE

Question 8

Trace amounts of this immunoglobulin is found in blood

Answer 8

IgD

Question 9

This immunoglobulin has a half-life of 26 days

Answer 9

IgG

Question 10

This immunoglobulin is the first to appear on lymphocyte’s membrane

Answer 10

IgM

Question 11

This immunoglobulin usually exists as a monomer but some are dimers and trimers

Answer 11

IgA

Question 12

This immunoglobulin is involved in immediate hypersensitivity reactions

Answer 12

IgE

Question 13

This immunoglobulin occurs in large amounts on B lymphocyte plasma membrane

Answer 13

IgD

Question 14

This immunoglobulin is a major opsonization antibody

Answer 14

IgG

Question 15

This immunoglobulin is predominant in the early primary response to most antigens

Answer 15

IgM

Question 16

This immunoglobulin can be inactivated by protease produced by various bacteria

Answer 16

IgA

Question 17

This immunoglobulin is involved in immunity to parasites

Answer 17

IgE

Question 18

This immunoglobulin may have some antibody activity to a limited number of antigens

Answer 18

IgD

Question 19

This immunoglobulin activates complement via classical pathway

Answer 19

IgG

Question 20

Predominant immunoglobulin produced in the fetus; elevated in cord blood may be indication of an infection before birth

Answer 20

IgM

Question 21

This immunoglobulin can consists of 2 monomers, J chain, and a secretory component

Answer 21

IgA

Question 22

This immunoglobulin is produced by B lymphocytes and plasma cells that are located primarily in the spleen, tonsils, adenoids, and lining the respiratory and digestive tracts

Answer 22

IgE

Question 23

This immunoglobulin may have some antibody activity to a limited number of antigens

Answer 23

IgD

Question 24

This immunoglobulin contains 2 heavy and 2 light chains

Answer 24

IgG

Question 25

Primary immunoglobulin made to carbohydrate antigens

Answer 25

IgM

Question 26

Which cells have an IgG receptor?

Answer 26

- Monocytes - Macrophages - Mast cells - Neutrophils - Eosinophils - Dendritic cells - B cells - NK cells

Question 27

Which cells have an IgE receptor?

Answer 27

- Mast cells - Eosinophils - Basophils

Question 28

Which cells add the secretory component to IgA?

Answer 28

Epithelial cells

Question 29

Which immunoglobulin is a pentamer?

Answer 29

IgM

Question 30

Which immunoglobulin could be a monomer, dimer, or trimer

Answer 30

IgA

Question 31

Which genes are used to make the light chain of an immunoglobulin

Answer 31

V and J genes

Question 32

Which genes are used to make the heavy chain?

Answer 32

V, J, D genes

Question 33

Which immunoglobulin is the first produced in an immune reaction?

Answer 33

IgM

Question 34

Effector functions of Abs

Answer 34

- Neutralization - Opsonization - Complement - ADCC

Question 35

What are the 3 pathways of complement activation

Answer 35

- Classical - Alternative - Lectin

Question 36

Which complement is used in properdin?

Answer 36

Alternative

Question 37

Which complement is dependent on Abs?

Answer 37

Classical

Question 38

In the classical pathway of complement, what is the C3 esterase?

Answer 38

C4b2a

Question 39

In the classical pathway of complement, what is the C5 convertase?

Answer 39

C4B2a3b

Question 40

What is the membrane attack complex?

Answer 40

C5b-C9 complex that forms pores to lyse target cells

Question 41

How does a cytotoxic T cell kill a virally infected cell?

Answer 41

Releases perforin and granzymes to induce apoptosis

Question 42

What is the role of Factor D in the alternative pathway?

Answer 42

Cleaves Factor B, activating the pathway

Question 43

How is mannose-binding lectin pathway activated?

Answer 43

- Binds to mannose on microbes - Activates MASPs

Question 44

Which molecule is the pivotal one in all 3 pathways?

Answer 44

C3

Question 45

Which hypersensitivity reaction is dependent on IgE?

Answer 45

Type I (allergic reaction)

Question 46

What is the shocking dose?

Answer 46

2nd exposure that causes an allergic response

Question 47

What is the roles of mast cells in type I reactions

Answer 47

Degranulate and release histimine upon IgE activation

Question 48

Antibodies involved in Type II and II reactions

Answer 48

- IgG - IgM

Question 49

Difference between type II and III reactions

Answer 49

- Type II: Antibodies bind cells **directly** - Type III: Antigen-antibody complexes deposit in tissues

Question 50

Which hypersensitivity reaction doesn’t involve antibodies?

Answer 50

Type IV (t-cell mediated)