Immunity to Eukaryotic Pathogens

Question 1

PMNs important for

Answer 1

Asperigillus
Mucor
Candida

Question 2

Macrophage important for

Answer 2

Pneumocystis, cryptococcus, blastomyces, histoplasma, aspergillus

Question 3

Opsonic phagocytosis

Answer 3

Use complement or AB

Question 4

Non-opsonic phago

Answer 4

B glucan receptors (dectin 1, pneumo, candidia, asperigllus, coccidiodes)
Mannose receptor (Candida, coccidiodes, pneumo) and TLRs (TLR2,4 and cryptococus)

Question 5

CD4s

Answer 5

Provide help to phagos and B cells..produce IFNgamma and TNFalpha

Question 6

Th1 immunity

Answer 6

Histoplasma, cryptococcus, blastomyces, aspergillus

Question 7

CD8

Answer 7

Histoplasma and blastomyces

Question 8

Granuloma formation

Answer 8

Important with histoplasma and many fungi will produce DTH response

Question 9

HUmoral immunity

Answer 9

Cryptococcus and pnuemo

Question 10

Macrophages will produce

Answer 10

IL-10, 12, and 18 that help mature dendritic cell

Question 11

Th1 produces

Answer 11

IFNgamma and TNFalpha to help activate macros

Question 12

Th2 produce

Answer 12

IL4 and 5 impotant for B cell

Question 13

Th17 produces

Answer 13

IL-17 important for neutrophil activation

Question 14

Plasmodium dzs and principal immune mechs

Answer 14

Malaria

ABs and CD8s

Question 15

Leishmania dzs and mechs

Answer 15

Leischmaniasis

CD4 Th1 cells help activate macros

Question 16

Trypanosoma dz and mech

Answer 16

Trypanosomiasis

ABs

Question 17

Entamoeba histolytica dz and mech

Answer 17

Amebiasis

ABs and phago

Question 18

Schistosoma dz and mech

Answer 18

Schistosomiasis

Esosinophils and macros

Question 19

Filaria dz and mech

Answer 19

Filariasis

CMI and ABs?

Question 20

Eosinophil act mech

Answer 20

Th2 produces IL-5 which activates Fc epsilon rceptor of the mast cell

Question 21

Th2 production against helminths

Answer 21

IL-13 increases production of epithelial cells…more mucous
IL-5 recruits eosinophils
IL-4 drives B cells to produce IgE
IL-3 and IL-9 recruit mast cells to tissue (cause muscle spasms, diarrhea that expel)

Question 22

Th1 production against helminths

Answer 22

IFNgamma activates macrophages and disrupts infected tissues
Also helps produce IgG which has not effect against helminths

Question 23

Malaria innate response in liver

Answer 23

Produce type 1 IFNs and IFN gamma

Question 24

Malaria adaptive liver response

Answer 24

Depends on CD8 cells

Question 25

Malaria blood stage immunity

Answer 25

Th1 cells protect with IL-10 and IFNgamma activation...Th2 cells induce AB response

Question 26

Toxoplasma gondii gut mucosal response

Answer 26

Gets through gut and activates Th1 cells to produce IFNgamma to activate monos and macros to kill parasite

Question 27

IFNgamma sources for toxoplasm defense

Answer 27

CD4 NK cell (activated by IL-12 from dendritic) Neutrophil CD8 (activated by infected dendritic) All prime the macro to kill by NO toxicity and decreased tryptophan