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Flashcards in Immuno 1 Deck (9)
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1
Q

This image shows an antigen-presenting cell activating a CD4 Th cell. Identify (A-E), which all activate the Th cell.

A mutation in which receptor would result in Hyper-IgM?

A

(A) MHC II;

(B) T-cell receptor;

(C) CD4;

(D) B7 Cd80/86

(E) CD28

2
Q

Which complement fragments degranulate mast cells

A

C3a, C5a

3
Q

How is the classic pathway activated?

How is the alternative pathway of the complement system activated?

How is the lectin pathway of the complement system activated?

A

By IgG/IgM antigen-antibody complexes (GM makes classic cars)

Microbial surface molecules

4
Q

How is the membrane attack complex (MAC) is formed? What organisms does the MAC complex protect us from?

A

C5 is cleaved to c5a and c5b

C5b joins with C6-9

5
Q

How is the lectin pathway of the complement system activated?

A

Mannose or other sugars found on microbial surface

6
Q

What are the two primary opsonins

A

Opsonization and clearance of immune complex;

C3b binds bacteria

Opsonization and clearance of immune complex;

IgG

7
Q

A pt has hives, diaphoresis, & shortness of breath after eating peanuts. Which complement proteins are involved?

A

C3a, C4a, C5a—anaphylaxis

8
Q

How is C3 convertase different when converted from the classical vs the other 2 pathways

A

Classic–> C3b-BB

Other–>C4b2b

9
Q

What 2 components prevent complement activation on self cells?

A

Decay-accelerating factor (DAF, also known as CD55) & C1 esterase inhibitors