Immuno

Question 1

Coeliac disease associated HLA

Answer 1

DQ2

Question 2

Scleroderma syx

Answer 2

Hard, thickening, shiny, tight skin

Question 3

Syndrome associated with limited scleroderma

Answer 3

CREST syndrome
C- calcinosis
R- reynauds
E- oesophageal dysmotility (GORD)
S- sclerodactyly (thick skin fingers)
T- telangiectasia

Question 4

Goodpasture syndrome presentation

Answer 4

Haemoptysis (inflamm and bleeding in lungs)

Haematuria

Question 5

SLE presentation

Answer 5

malar rash, photosensitivity, fatigue, arthritis, mouth ulcers

Question 6

What type of hypersensitivity reaction is SLE?

Answer 6

Type 3

Question 7

Which antibody is responsible for protecting against GI infx?

Answer 7

IgA

Question 8

What is a subunit/component vaccine?

Answer 8

use of antigenic proteins

Question 9

Example of subunit vaccines

Answer 9

HPV - capsid

Question 10

What is a conjugate vaccine?

Answer 10

polysaccharide + protein to invoke a strong reaction, used against encapsulated bacteria

Question 11

Example of a conjugate vaccine

Answer 11

NHS
Neisseria meningitidis
Haemophilus influenzae
Streptotoccus pneumonia

Question 12

Which vaccination is not safe for HIV patients?

Answer 12

Yellow fever

Question 13

What is a live attenuated vaccine?

Answer 13

Weakened live pathogens

Question 14

Live attenuated vaccine examples

Answer 14

MMR, VZV, rotavirus, Yellow Fever

Question 15

Which live attenuated vaccine is safe for HIV pts?

Answer 15

MMR

Question 16

Which receptor does Ipilimumab (Rx for met melanoma) bind to?

Answer 16

CTLA4

Question 17

Which MHC is most important when matching donors?

Answer 17

DR (>B>A)

Question 18

What is an inactivated vaccine?

Answer 18

Destroyed pathogens or their components, not able to replicate

Question 19

Inactivated vaccine example

Answer 19

Pertussis, influenza, rabies

Question 20

What type are the COVID vaccines?

Answer 20

DNA/RNA