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Flashcards in immunologic + shock + etc Deck (313)
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1

receptor and reservoir for HIV

T4 (CD4) cells

2

HIV modes of transmission x4

- blood
- semen
- vaginal secretions
- breast milk

3

HIV sero conversion: defn, s/s, & time frame

- conversion HIV - to +
- flu-like sx (early: fever, night sweats, weight loss)
- 3 wk to 6 mo

4

AIDS defn

CD4

5

HIV: initial screening tool

ELISA (sens > 99.9%)

6

HIV: confirmatory test

Western Blot

7

absolute CD4 lymphocyte count: normal

> 800 cells/uL

8

high risk of progression to AIDS @ ? CD4 lymphocyte %

20%

9

HIV: viral load what + how

- correlates closely with progression of HIV (ideally undetectable)
- PCR

10

pneumocystis jirovecii (opportunistic infection) prophylactic tx in HIV+

bactrim

11

AART - what + when

active antiretroviral therapy
- controversial: some experts = start @ time of dx / CDC rec = all pts on AART by CD4 = 350/uL

12

osteoarthritis is...

degenerative joint disease
- slow destruction of articular cartilage

13

OA: damage type

articular cartilage destruction

14

rheumatoid arthritis is...

systemic autoimmune disease
- inflammation of connective tissue

15

RA: damage type

inflammation of connective tissue

16

inflammation OA vs RA

OA: asymmetrical
RA: symmetrical

17

OA vs RA gender impacted

OA: equal
RA: women 3:1

18

OA: joints involved

- weight-bearing (knees/hips) + fingers, hands, wrists
- heberden's & bouchard's nodes

19

RA: joints involved

proximal interphalangeal joints (PIPs)
metacarpophalangeal joints (MCPs)
wrists

20

OA: joint sx

swelling, edema W/O erythema/heat

21

RA: joint sx

swelling, edema, erythema, "heat"

22

heberden's nodes

OA: distal interphalangeal joints (DIPs)

23

bouchard's nodes

OA: proximal interphalangeal joints (DIPs)

24

metacarpophalangeal joints are

knuckles

25

OA: pain progression

AM: better - worsens as day progresses
- aggravated by activity & relieved by rest

26

RA: pain progression

AM: worse - improves as day progresses

27

OA or RA: aggravated by activity / relieved by rest

OA

28

OA or RA: angular deformities of affected joints

OA

29

OA or RA: autoimmune w multifactorial etiology

RA

30

OA or RA: fatigue, weakness, malaise, anorexia, wt loss

RA