Immunology Flashcards Preview

USMLE Step 1: Things I Cannot Remember > Immunology > Flashcards

Flashcards in Immunology Deck (17):
1

HLA A3

Hemochromatosis

2

HLA B27

PAIR

  • Psoriatic arthritis
  • Ankylosing Spondylitis
  • Inflammatory Arthritis
  • Reactive Arthritis (Reiter Syndrome)

3

HLA DQ2/DQ8

Celiac Disease

4

HLA DR2

  • MS
  • Hay fever
  • SLE
  • Goodpasture's syndrome

5

HLA DR3

  • DM1
  • SLE
  • Grave's disease
  • Hashimoto thyroiditis

6

HLA DR4

Rheumatoid Arthritis, DM1

7

HLA DR5

  • Pernicious Anemia
    • leads to Vitamin B12 deficiency
  • Hashimoto thyroiditis

8

Pure B-cell disorders:

  1. X-linked (Bruton) agammaglobulinemia
  2. Selective IgA deficiency
  3. CVID

9

Pure T-cell disorders:

  1. Thymic aplasia (DiGeorge syndrome)
  2. IL12-receptor deficiency
  3. Autosomal dominant hyper IgE syndrome (Job syndrome)
  4. Chronic mucocutaneous candidiasis

10

B and T cell disorders:

  1. SCID
  2. Ataxia-telengiectasia
  3. Hyper-IgM syndrome
  4. Wiskott-Aldrich syndrome

11

Phagocyte dysfunction:

  1. Leucocyte adhesion deficiency (LAD) type 1
  2. Chediak-Higashi syndrome
  3. Chronic granulomatous disease (CGD)

12

What is the most common primary immunodeficiency?

Selective IgA deficiency

13

What is deficient in heriditary angioedema?

C1 esterase inhibitor deficiency

14

What are the features of C3 deficiency?

  • severe, recurrent pyogenic sinus and respiratory tract infections
  • ↑ susceptibility to type III hypersensitivity

15

What are the features of C5-C9 deficiencies?

↑ susceptibility to recurrent Neisseria bactermia

16

What does DAF (GPI-anchored enzyme) deficiency lead to?

  • Complement-mediated lysis of RBCs
  • Paroxysmal nocturnal hemoglobinuria (PNH)

17